Functions of Dendritic Cells and Its Association with Intestinal Diseases

Yang, Ze-Jun; Wang, Bo-Ya; Wang, Tiantian; Wang, Feifei; Guo, Yuexin; Hua, Rongxuan; Shang, Hongcai; Lü, Xin; Xu, Jin

doi:10.3390/cells10030583

Cited by 23 publications

(16 citation statements)

References 154 publications

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“…It is not clear if DCs also affect the transmission of pathogenic bacteria and their toxic metabolites to the liver through the portal vein. The existing fact remains that the physiological action of DCs can be affected by the intestinal microbes ( Yang et al, 2021 ). On the other hand, numerous researches have proved that migratory DCs could dominate induction of enteric T regulatory cells to manage commensal bacteria or to set up oral tolerance targeted at dietary antigens ( Esterházy et al, 2016 ; Esterházy et al, 2019 ; Russler-Germain et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Exploration of Shared Gene Signatures and Molecular Mechanisms Between Periodontitis and Nonalcoholic Fatty Liver Disease

Zhang

Yao

et al. 2022

Front. Genet.

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Background: Periodontitis is associated with periodontal tissue damage and teeth loss. Nonalcoholic fatty liver disease (NAFLD) has an intimate relationship with periodontitis. Nevertheless, interacted mechanisms between them have not been clear. This study was intended for the exploration of shared gene signatures and latent therapeutic targets in periodontitis and NAFLD.Methods: Microarray datasets of periodontitis and NAFLD were obtained from the Gene Expression Omnibus (GEO) database. The weighted gene co-expression network analysis (WGCNA) was utilized for the acquisition of modules bound up with NAFLD and periodontitis. We used ClueGO to carry out biological analysis on shared genes to search their latent effects in NAFLD and periodontitis. Another cohort composed of differential gene analysis verified the results. The common microRNAs (miRNAs) in NAFLD and periodontitis were acquired in the light of the Human microRNA Disease Database (HMDD). According to miRTarbase, miRDB, and Targetscan databases, latent target genes of miRNAs were forecasted. Finally, the miRNAs–mRNAs network was designed.Results: Significant modules with periodontitis and NAFLD were obtained via WGCNA. GO enrichment analysis with GlueGo indicated that damaged migration of dendritic cells (DCs) might be a common pathophysiologic feature of NAFLD and periodontitis. In addition, we revealed common genes in NAFLD and periodontitis, including IGK, IGLJ3, IGHM, MME, SELL, ENPP2, VCAN, LCP1, IGHD, FCGR2C, ALOX5AP, IGJ, MMP9, FABP4, IL32, HBB, FMO1, ALPK2, PLA2G7, MNDA, HLA-DRA, and SLC16A7. The results of differential analysis in another cohort were highly accordant with the findings of WGCNA. We established a comorbidity model to explain the underlying mechanism of NAFLD secondary to periodontitis. Finally, the analysis of miRNA pointed out that hsa-mir-125b-5p, hsa-mir-17-5p, and hsa-mir-21-5p might provide potential therapeutic targets.Conclusion: Our study initially established a comorbidity model to explain the underlying mechanism of NAFLD secondary to periodontitis, found that damaged migration of DCs might be a common pathophysiological feature of NAFLD and periodontitis, and provided potential therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

Exploration of Shared Gene Signatures and Molecular Mechanisms Between Periodontitis and Nonalcoholic Fatty Liver Disease

Zhang

Yao

et al. 2022

Front. Genet.

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“…In the intestine, dendritic cells are widely distributed within the lamina propria, and they are one of the immune cells central to the initiation of protective proinflammatory as well as tolerogenic immune response, which are pivotal in the maintenance of intestinal homeostasis ( Persson et al, 2010 ; Persson et al, 2013 ; Worbs et al, 2017 ). For a long time, studies have focused on the relationship between DCs and intestinal diseases including inflammatory bowel disease and intestinal neoplasms ( Bernardo et al, 2018 ; Yang Z. J. et al, 2021 ). Considering the inflammatory reaction and immune response in POI, it could be logically inferred that DCs play an irreplaceable role in the pathogenesis and development of this disease.…”

Section: Immune Cells In Postoperative Ileusmentioning

confidence: 99%

Molecular and cellular mechanisms underlying postoperative paralytic ileus by various immune cell types

et al. 2022

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Postoperative ileus (POI) is a well-known complication following gut manipulation or surgical trauma, leading to an impaired gut motility and prolonged postoperative recovery time. Few current therapeutic strategies can prevent POI, and this disorder remains to be a major clinical challenge for patients undergoing surgery. Comprehensive understanding of cellular and molecular mechanisms related to the pathogenesis of POI stimulates the discovery of more promising targets for treatment. POI is closely associated with a series of inflammatory events within the bowel wall, and as key components of inflammatory mechanisms, different types of immune cells, including macrophages, dendritic cells, and T lymphocytes, play significant roles during the development of POI. A variety of immune cells are recruited into the manipulation sites after surgery, contributing to early inflammatory events or impaired gut motility. Our review intends to summarize the specific relationship between different immune cells and POI, mainly focusing on the relevant mechanisms underlying this disorder.

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“…Intestinal lymphocytes are continuously exposed to food and microbial antigens via antigen presenting cells (APC) including dendritic cells (DCs). DCs present in GALT and lamina propria have a high tolerogenic potential and a break of this tolerance triggers inflammation leading to IBD or cancer (for review, see [39][40][41]. These lymphocytes help to maintain the integrity of the intestinal barrier and immune homeostasis.…”

Section: The Intestinal Immune Systemmentioning

confidence: 99%

Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer

et al. 2021

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The gastrointestinal tract is a complex interface between the external environment and the immune system. Its ability to control uptake across the mucosa and to protect the body from damage of harmful substances from the lumen is defined as the intestinal barrier function (IBF). The IBF involves four elements: the intestinal microbiota, the mucus layer, the epithelium and the immune system. Its dysfunction is linked with human diseases including inflammatory, metabolic, infectious, autoimmune and neurologic disorders. Most of these diseases are complex and involve genetic, psychological and environmental factors. Over the past 10 years, many genetic polymorphisms predisposing to inflammatory bowel disease (IBD) have been identified. Yet, it is now clear that they are insufficient to explain the onset of these chronic diseases. Although it has been evidenced that some environmental factors such as cigarette smoking or carbohydrate intake are associated with IBD, other environmental factors also present potential health risks such as ingestion of food additives introduced in the human diet, including those composed of mineral particles, by altering the four elements of the intestinal barrier function. The aim of this review is to provide a critical opinion on the potential of TiO2 particles, especially when used as a food additive, to alter the four elements of the intestinal barrier function, and consequently to evaluate if this additive would likely play a role in the development and/or exacerbation of IBD.

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Functions of Dendritic Cells and Its Association with Intestinal Diseases

Cited by 23 publications

References 154 publications

Exploration of Shared Gene Signatures and Molecular Mechanisms Between Periodontitis and Nonalcoholic Fatty Liver Disease

Exploration of Shared Gene Signatures and Molecular Mechanisms Between Periodontitis and Nonalcoholic Fatty Liver Disease

Molecular and cellular mechanisms underlying postoperative paralytic ileus by various immune cell types

Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer

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