Functionalized Benzofurans via Microwave‐Promoted Tandem Claisen‐Rearrangement/5‐<scp><i>endo</i></scp>‐dig Cyclization

Schultze, Christiane; Schmidt, Bernd

doi:10.1002/jhet.3671

Cited by 4 publications

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References 46 publications

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“…Microwave promoted approach towards the preparation of 7-allylsubstituted benzofurans from ortho-allyloxyalkenyl benzenes was established (Scheme 19). 53 The reaction was described to proceed via Claisen-rearrangement, followed by 5-endo-dig-cyclization forming OMe…”

Section: Scheme 18 Synthesis Of 23-disubstituted Benzo[b]furansmentioning

confidence: 99%

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

Anilkumar¹,

Aneeja²,

Afsina³

2021

HETEROCYCLES

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Microwave (MW) assisted syntheses are environment friendly, efficient, rapid and convenient methodology for the synthesis of organic compounds. Benzene ring fused to a five membered ring containing N or O atom exhibits wide range of biological activities.Benzofuran is present in polymers, pharmaceuticals, and bioactive natural products.Benzofuran is significant as insecticides, herbicides, anti-inflammatory and anti-viral agents.Indoles are well known scaffold showing noteworthy activities like anti-tumor, anti-viral, anti-microbial and anti-oxidant. Indole derivatives are valuable moiety in different therapeutically active drug molecules. On account of the biological significance of benzofuran and indole scaffold, this review describes the recent advances in microwave assisted synthesis of benzofurans and indoles, and covers literature from 2012-2020.

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Section: Scheme 18 Synthesis Of 23-disubstituted Benzo[b]furansmentioning

confidence: 99%