Functionalized 3-(benzofuran-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole scaffolds: A new class of antimicrobials and antioxidants

Rangaswamy, Javarappa; Kumar, Hemant; Harini, Salakatte Thammaiah; Naik, Nagaraja

doi:10.1016/j.arabjc.2013.10.012

Cited by 27 publications

(16 citation statements)

References 25 publications

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“…Structure-activity relationship revealed that the presence of electron-donating and halo functionalities increased antioxidant activity. A novel class of antioxidant based 3-(benzofuran-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole structure was studied by Rangaswamy and co-workers 8 . Compound (3) displayed a dominant scavenging performance against three radicals: DPPH, LPO and ABTS with IC 50 values of 9, 4.3 and 18.9 μM, respectively.…”

Section: Antioxidantmentioning

confidence: 99%

Some Bioactivities of Heterocyclic Compounds Containing Pyrazoline Moiety A Short Review

Ardiansah¹

2018

IJCTR

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Current research on chemistry of heterocyclic compounds is particularly focused on the development of diversity-oriented molecules containing nitrogen atom in the form of pyrazoline. Although less familiar than pyrazoles, they have shown to exhibit appreciable biological activities. This review highlights some pyrazoline compounds as promising agents for antioxidant, antitrypanosomal, antitubercular, antitumor and MAO inhibitor.

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Section: Antioxidantmentioning

confidence: 99%

Some Bioactivities of Heterocyclic Compounds Containing Pyrazoline Moiety A Short Review

Ardiansah¹

2018

IJCTR

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“…Meanwhile, against S. aureus and E. coli, it showed good performance with MIC 20 μg/mL, same with Streptomycin as positive control. A novel class of 3-(benzofuran-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole derivatives was designed by Rangaswamy et al [80]. Using well plate method for antimicrobial assay, compound (72) and (73) exhibited good inhibitory activity against E. coli, S. aureus, and P. aeruginosa.…”

Section: Research In 2017mentioning

confidence: 99%

A Recent Update: Antimicrobial Agents Containing Pyrazole Nucleus

Ardiansah

2018

Asian J Pharm Clin Res

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Objective: In this review, we report antimicrobial candidates containing pyrazole nucleus integrated with various functionalities.Methods: research results by numerous scientists have been summarized from international journals indexed in reputed database such as Scopus and Web of Science.Results: Pyrazole derivatives are much of interest as potent bioactive molecules. They have shown large bioactivities especially antimicrobial performance against broad spectrum of bacterial strains.Conclusion: Several designed pyrazole derivates possessed good to superior antimicrobial activities.

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“…Numerous synthesized benzofuran derivatives were found to be biologically active [7][8][9]. Now a days many synthetic benzofurans are used as good inhibitor [10,11], antimicrobial [12][13][14], anti-inflammatory [15,16], antiviral [17], antioxidant [18,19], anti-tumour [20], antiproliferative [21,22] and anti-alzheimer [23] (Fig. 2).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of new benzofuran carboxamide derivatives

Lavanya

Sribalan

Padmini

2017

Journal of Saudi Chemical Society

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A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(b-alanamido)-benzo furan-2-carboxamide derivatives (5a-o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging activities. The synthesized compounds were characterized by NMR, IR, Mass and X-ray crystallographic techniques. ª 2015 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Functionalized 3-(benzofuran-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole scaffolds: A new class of antimicrobials and antioxidants

Cited by 27 publications

References 25 publications

Some Bioactivities of Heterocyclic Compounds Containing Pyrazoline Moiety A Short Review

Some Bioactivities of Heterocyclic Compounds Containing Pyrazoline Moiety A Short Review

A Recent Update: Antimicrobial Agents Containing Pyrazole Nucleus

Synthesis and biological evaluation of new benzofuran carboxamide derivatives

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