Functionality During the First Five Years After the Diagnosis of Schizophrenia. A Cohort Study in a Colombian Population

Cano, Juan Fernando; Pedraza-Perez, Carlos; Córdoba-Rojas, Rodrigo Nel; Vallejo-Silva, Alexie; González-Díaz, Jairo M.

doi:10.1016/j.rcp.2020.11.005

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…Unfortunately, even though Latin America comprises 20 countries and more than 600 million people, very few longitudinal FE studies have been conducted and only a handful of specialized FE teams have been established, mostly in Brazil, Chile and Mexico (Aceituno et al, 2020). Based on our literature review, we just found three clinical trials (Apiquian et al, 2003;Valencia et al, 2012;Valencia et al, 2017), few reports describing a naturalistic follow-up of clinical samples (Attux et al, 2007;Trzesniak et al, 2012;Gonzalez-Valderrama., 2017;Cano et al, 2021), a number of short, acute treatment studies used to examine neuroimaging or genetic markers (De La Fuente-Sandoval et al, 2013;Santoro et al, 2018) or chart reviews with a longitudinal component (Gomez-de-Regil et al, 2010;Markkula et al, 2011;Mena et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Predictors of Treatment Response, Remission, Relapse and Rehospitalization in First-Episode Psychosis Patients in Medellin, Colombia

García¹,

Agudelo²,

M³

et al. 2021

Preprint

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BackgroundMost studies with first episode psychosis patients have been conducted in high-income countries. On the other hand, very few first episode studies have been conducted in Latin-America. Therefore, the goal of our study is to determine predictors of treatment response, remission, relapse and rehospitalization in a first episode psychosis population from Medellin, Colombia.MethodsData was obtained from electronic health records from first episode patients with a diagnosis of schizophrenia-spectrum disorder diagnoses who were evaluated between January 2014 and December 2016 at two psychiatric institutions in Medellin, Colombia. Survival and Cox proportional hazard models were used for the analysis.ResultsDuration of untreated psychosis and hospitalization at the time of presentation was associated with both response and remission. Response was also predicted by less first-order symptoms and more years of education. Remission was predicted by older age of onset. Relapse and rehospitalization were predicted by use of substances and poor adherence to pharmacologic treatment. Less years of education and hospitalization at the time of presentation were also associated with rehospitalization.ConclusionPredictors of treatment response, remission, relapse and rehospitalization in first-episode patients are similar in Colombia compared to other high-income regions such as the United States and Europe.

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