Functionalisation of nanoparticles for biomedical applications

Thanh, Nguyễn Thị Kim; Green, Luke A. W.

doi:10.1016/j.nantod.2010.05.003

Cited by 624 publications

(381 citation statements)

References 230 publications

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“…240 Although nanostructures without specific targeting agents on the surface (also called passive targeting), which rely on enhanced permeation and retention (EPR) effects (owing to the leaky blood vessels of tumor sites) have been employed for various biomedical applications, they typically exhibit poor results. Typical chemical synthesis of magnetic nanostructures results in hydrophobic hydrocarbons.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Magnetic nanoparticles: recent advances in synthesis, self-assembly and applications

et al. 2011

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Nanostructured magnetic materials have a variety of promising applications spreading from nano-scale electronic devices, sensors and high-density data storage media to controlled drug delivery and cancer diagnostics/treatment systems. Magnetic nanoparticles offer the most natural and elegant way for fabrication of such (multi-) functional materials. In this review, we briefly summarize the recent progress in the synthesis of magnetic nanoparticles (which now can be done with precise control over the size and surface chemistry), and nanoscale interactions leading to their self-assembly into 1D, 2D or 3D aggregates. Various approaches to self-organization, directed-, or template-assisted assembly of these nanostructures are discussed with the special emphasis on magnetic-field enabled interactions. We also discuss new physical phenomena associated with magnetic coupling between nanoparticles and their interaction with a substrate and the characterization of the physical properties at the nanoscale using various experimental techniques (including scanning quantum interferometry (SQUID) and magnetic force microscopy). Applications of magnetic nanoparticle assemblies in data storage, spintronics, drug delivery, cancer therapy, and prospective applications such as adaptive materials and multifunctional reconfigurable materials are also highlighted.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Magnetic nanoparticles: recent advances in synthesis, self-assembly and applications

et al. 2011

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“…Cationic surfactant CTAB was chosen as the phase transfer agent to convert QDs from organic phase to aqueous phase [34]. The experimental process of preparing monodispersed water-soluble CTAB-coated CdSe/ZnS QDs is schematically illustrated in Fig.…”

Section: Characterization Of Ctab-coated Cdse/zns Qdsmentioning

confidence: 99%

Rapid detection of vegetable cooking oils adulterated with inedible used oil using fluorescence quenching method with aqueous CTAB-coated quantum dots

Xiong

et al. 2014

Sensors and Actuators B: Chemical

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a b s t r a c tVegetable cooking oils adulterated with inedible used oils or impure oils have posed a severe food safety problem. Current detection methods cannot meet the needs for rapid detection of adulterated oils on line or in field. Therefore, the objective of this research was to develop a rapid optical sensing method based on fluorescence quenching of CdSe/ZnS quantum dots (QDs) for identification of adulterated vegetable cooking oils. High quality hydrophilic photoluminescent nanoparticles were synthesized by encapsulating hydrophobic QDs into the micellar structure of an amphiphilic surfactant cetyltrimethyl ammonium bromide (CTAB) via phase transfer method. TEM, AFM, and fluorescence spectroscopy were used to characterize the prepared CTAB-coated QDs. Oil samples were first captured into the core of the twolayer-structural micelle and then the fluorescence of CTAB-coated QDs, working as fluorescence probes, was selectively quenched by components of the adulterated oils. Heavy metal ions and free radicals were presumed to be main quenchers. After quenching for 1 min, fluorescence intensity was measured and converted to quenching percentage to determine the adulteration concentration. The results showed that in comparison with oil-soluble QDs, water-soluble CTAB-coated QDs had a greater ability to identify oil adulteration. A good quantitative relationship between quenching percentage and adulteration concentration (y = 5.96x + 14.99; R 2 = 0.94) was obtained. The sensitive, simple and low-cost sensing method did not require sample pretreatment and could detect refined used oils at 0.4% or higher concentrations in soybean oil within 2 min, showing great potentials for rapid screening of used oils and quantitative analysis of used oil adulteration in field.

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“…[138] Although a well dispersion of such MNPs can make ferrofluids in non-polar media such as toluene, hexane or chloroform, a phase transfer into aqueous media of the nanocrystals is required before their in vivo injection. [139] In particular, a surface functionalization with biocompatible material is essential to enable their dispersion in polar solvents such as water. Two basic strategies are ligand addition and ligand exchange, where the former involves addition of a biocompatible coating on top of the original coating, [140] while the latter strategy involves removal of the original coating and replacing it by another biocompatible coating.…”

Section: Thermal Decompositionmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Functionalisation of nanoparticles for biomedical applications

Cited by 624 publications

References 230 publications

Magnetic nanoparticles: recent advances in synthesis, self-assembly and applications

Magnetic nanoparticles: recent advances in synthesis, self-assembly and applications

Rapid detection of vegetable cooking oils adulterated with inedible used oil using fluorescence quenching method with aqueous CTAB-coated quantum dots

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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