Functional Selection of Adaptive Auditory Space Map by GABA
            <sub>A</sub>
            -Mediated Inhibition

Zheng, Weimin; Knudsen, Eric I.

doi:10.1126/science.284.5416.962

Cited by 116 publications

(76 citation statements)

References 18 publications

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“…An important structure within this chain is the midbrain inferior colliculus (IC), because it acts as the primary relay center between ascending projections from the lower brainstem nuclei and ascending projections to the thalamus. Because of its unique makeup of converging ascending and corticofugal projections (Irvine, 1992;Zhang and Suga, 2005), animal studies have identified the IC as a site of both activity-and experience-dependent developmental plasticity in both vertebrate and, most recently, mammalian brains (Brainard and Knudsen, 1993;Knudsen, 1998;Zheng and Knudsen, 1999;DeBello et al, 2001;Yu et al, 2007). However, similar studies on developmental plasticity in the human auditory brainstem have been limited primarily because of the obvious limitations in the use of parallel technique and experimental design.…”

Section: Introductionmentioning

confidence: 97%

Developmental Plasticity in the Human Auditory Brainstem

Johnson¹,

Nicol²,

Zecker³

et al. 2008

J. Neurosci.

145

126

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Development of the human auditory brainstem is thought to be primarily complete by the age of ϳ2 years, such that subsequent sensory plasticity is confined primarily to the cortex. However, recent findings have revealed experience-dependent developmental plasticity in the mammalian auditory brainstem in an animal model. It is not known whether the human system demonstrates similar changes and whether experience with sounds composed of acoustic elements relevant to speech may alter brainstem response characteristics. We recorded brainstem responses evoked by both click and speech syllables in children between the ages of 3 and 12 years. Here, we report a neural response discrepancy in brainstem encoding of these two sounds, observed in 3-to 4-year-old children but not in school-age children. Whereas all children exhibited identical neural activity to a click, 3-to 4-year-old children displayed delayed and less synchronous onset and sustained neural response activity when elicited by speech compared with 5-to 12-year-olds. These results suggest that the human auditory system exhibits developmental plasticity, in both frequency and time domains, for sounds that are composed of acoustic elements relevant to speech. The findings are interpreted within the contexts of stimulus-related differences and experience-dependent plasticity.

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Section: Introductionmentioning

confidence: 97%

Developmental Plasticity in the Human Auditory Brainstem

Johnson¹,

Nicol²,

Zecker³

et al. 2008

J. Neurosci.

145

126

View full text Add to dashboard Cite

show abstract

“…In some sensorimotor systems, altered sensory experience can shift suprathreshold response patterns, whereas synapses conveying information about previously preferred stimuli are anatomically maintained but functionally suppressed, at least at the suprathreshold level (Zheng and Knudsen, 1999;Linkenhoker et al, 2005). We wondered whether LMAN neurons in plastic birds, while showing suprathreshold selectivity for the new BOS, might still exhibit purely subthreshold responses to the previously preferred stimulus, namely the old BOS.…”

Section: Loss Of Subthreshold Responsiveness To the Original Song Aftmentioning

confidence: 99%

Auditory Plasticity in a Basal Ganglia-Forebrain Pathway during Decrystallization of Adult Birdsong

Roy¹,

Mooney²

2007

Journal of Neuroscience

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Adult male zebra finches maintain highly stable songs via auditory feedback. Prolonged exposure to distorted feedback may cause this stable (i.e., "crystallized") song to change its pattern, a process known as decrystallization. In the songbird, the telencephalic nucleus LMAN (lateral magnocellular nucleus of anterior nidopallium) is necessary for feedback-dependent song decrystallization, although whether and how electrophysiological properties of LMAN neurons change during decrystallization is unknown. In normal adult zebra finches, LMAN neurons exhibit highly selective responses to auditory presentation of the bird's own song (BOS), possibly providing a permanent referent for song maintenance. If so, LMAN neurons should maintain selectivity for the originally crystallized BOS after exposure to distorted feedback and during decrystallization. Alternatively, LMAN auditory selectivity in the adult may change during decrystallization. To distinguish between these possibilities, we sectioned the vocal nerve in adult male zebra finches, which spectrally distorted the birds' songs. Over the course of several weeks, experience of distorted feedback caused the song to decrystallize in a subset of birds. At various times after nerve section, electrophysiological recordings made under anesthesia revealed that auditory selectivity in LMAN could shift to the spectrally distorted song. Such auditory plasticity could be detected during the second week after nerve section, before the time birds typically decrystallized their songs. Moreover, all birds that underwent decrystallization at later times always manifested auditory plasticity in LMAN. To our knowledge, the present findings afford the first example of an electrophysiological correlate of song decrystallization.

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“…Experience-driven changes in the auditory space map are associated with corresponding changes in the topography of axonal projections from the ICC to the ICX (Feldman and Knudsen, 1997;DeBello et al, 2001) and with changes in patterns of both excitation and inhibition within the ICX (Zheng and Knudsen, 1999;Zheng and Knudsen, 2001).…”

Section: Introductionmentioning

confidence: 99%

Multiple Sites of Adaptive Plasticity in the Owl's Auditory Localization Pathway

DeBello

Knudsen²

2004

J. Neurosci.

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In the midbrain auditory localization pathway of the barn owl, a map of auditory space is relayed from the external nucleus of the inferior colliculus (ICX) to the deep and intermediate layers of the optic tectum (OT) and from these layers to the superficial layers. Within the OT, the auditory space map aligns with a visual map of space. Raising young barn owls with a prismatic displacement of the visual field leads to progressive changes in auditory tuning in the OT that tend to realign the auditory space map with the prismatically displaced visual space map. The only known site of this adaptive plasticity is in the ICX, in which the auditory system first creates a map of space. In this study, we identified an additional site of plasticity in the OT. In owls that experienced prisms beginning late in the juvenile period, adaptive shifts in auditory tuning in the superficial layers of the OT exceeded the adaptive shifts that occurred in the deep layers of the OT or in the ICX. Anatomical results from these owls demonstrated that the topography of intrinsic OT connections was systematically altered in the adaptive direction. In juvenile owls, plasticity in the OT increased as plasticity in the ICX decreased. Because plasticity at both sites has been shown to decline substantially in adults, these results suggest that an age-dependent decrease in auditory map plasticity occurs first in the ICX and later at the higher level, in the OT.

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Functional Selection of Adaptive Auditory Space Map by GABA _A -Mediated Inhibition

Cited by 116 publications

References 18 publications

Developmental Plasticity in the Human Auditory Brainstem

Developmental Plasticity in the Human Auditory Brainstem

Auditory Plasticity in a Basal Ganglia-Forebrain Pathway during Decrystallization of Adult Birdsong

Multiple Sites of Adaptive Plasticity in the Owl's Auditory Localization Pathway

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Functional Selection of Adaptive Auditory Space Map by GABA A -Mediated Inhibition

Cited by 116 publications

References 18 publications

Developmental Plasticity in the Human Auditory Brainstem

Developmental Plasticity in the Human Auditory Brainstem

Auditory Plasticity in a Basal Ganglia-Forebrain Pathway during Decrystallization of Adult Birdsong

Multiple Sites of Adaptive Plasticity in the Owl's Auditory Localization Pathway

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Functional Selection of Adaptive Auditory Space Map by GABA _A -Mediated Inhibition