Functional segmentation of the brain cortex using high model order group PICA

Kiviniemi, Vesa; Starck, Tuomo; Remes, Jukka; Long, Xiangyu; Nikkinen, Juha; Haapea, Marianne; Veijola, Juha; Moilanen, Irma; Isohanni, Matti; Zang, Yu‐Feng; Tervonen, Osmo

doi:10.1002/hbm.20813

Cited by 347 publications

(385 citation statements)

References 58 publications

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“…In the current experiment, the spatial resolution of the 3T EPI images combined with standard preprocessing and decomposition of the data with ICA does not allow for a robust extraction of components as small as the STN (Kiviniemi et al, 2009). Therefore, we used probability maps of the left and right STN (B.U.…”

Section: Discussionmentioning

confidence: 99%

“…Then, group-level aggregate data were generated by concatenating and reducing individual principal components in a second PCA step. Infomax ICA (Bell and Sejnowski, 1995) was performed in this set with a model order of 60 components (Kiviniemi et al, 2009). To estimate robust components we used ICASSO (Himberg et al, 2004), i.e., the decomposition was performed 100 times with random initial conditions, and identified centroids with a canonical correlation-based clustering.…”

Section: Methodsmentioning

confidence: 99%

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Neural Correlates of Trial-to-Trial Fluctuations in Response Caution

Maanen¹,

Brown²,

Eichele³

et al. 2011

J. Neurosci.

178

228

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Trial-to-trial variability in decision making can be caused by variability in information processing as well as by variability in response caution. In this paper, we study which neural components code for trial-to-trial adjustments in response caution using a new computational approach that quantifies response caution on a single-trial level. We found that the frontostriatal network updates the amount of response caution. In particular, when human participants were required to respond quickly, we found a positive correlation between trial-to-trial fluctuations in response caution and the hemodynamic response in the presupplementary motor area and dorsal anterior cingulate. In contrast, on trials that required a change from a speeded response mode to a more accurate response mode or vice versa, we found a positive correlation between response caution and hemodynamic response in the anterior cingulate proper. These results indicate that for each decision, response caution is set through corticobasal ganglia functioning, but that individual choices differ according to the mechanisms that trigger changes in response caution.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Neural Correlates of Trial-to-Trial Fluctuations in Response Caution

Maanen¹,

Brown²,

Eichele³

et al. 2011

J. Neurosci.

178

228

View full text Add to dashboard Cite

show abstract

“…The group‐level dimensionality for PCA and ICA decompositions (i.e., 61) was set to the minimum order to retain 100% nonzero Eigen values during individual PCA reduction, which is close estimate of the true degree of freedom in the data. The major purpose underlying this procedure was to use a high‐order decomposition [Kiviniemi et al, 2009] to maximize the observable effects while avoiding possible overfitting errors [Sarela and Vigario, 2003]. …”

Section: Methodsmentioning

confidence: 99%

Brain activity and connectivity during poetry composition: Toward a multidimensional model of the creative process

Liu

Erkkinen

Healey

et al. 2015

Human Brain Mapping

147

102

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Creativity, a multifaceted construct, can be studied in various ways, for example, investigating phases of the creative process, quality of the creative product, or the impact of expertise. Previous neuroimaging studies have assessed these individually. Believing that each of these interacting features must be examined simultaneously to develop a comprehensive understanding of creative behavior, we examined poetry composition, assessing process, product, and expertise in a single experiment. Distinct activation patterns were associated with generation and revision, two major phases of the creative process. Medial prefrontal cortex (MPFC) was active during both phases, yet responses in dorsolateral prefrontal and parietal executive systems (DLPFC/IPS) were phase‐dependent, indicating that while motivation remains unchanged, cognitive control is attenuated during generation and re‐engaged during revision. Experts showed significantly stronger deactivation of DLPFC/IPS during generation, suggesting that they may more effectively suspend cognitive control. Importantly however, similar overall patterns were observed in both groups, indicating the same cognitive resources are available to experts and novices alike. Quality of poetry, assessed by an independent panel, was associated with divergent connectivity patterns in experts and novices, centered upon MPFC (for technical facility) and DLPFC/IPS (for innovation), suggesting a mechanism by which experts produce higher quality poetry. Crucially, each of these three key features can be understood in the context of a single neurocognitive model characterized by dynamic interactions between medial prefrontal areas regulating motivation, dorsolateral prefrontal, and parietal areas regulating cognitive control and the association of these regions with language, sensorimotor, limbic, and subcortical areas distributed throughout the brain. Hum Brain Mapp 36:3351–3372, 2015. © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc..

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“…To fractionate the TPJ into more specific components, we used a local independent component analysis (ICA) analysis. ICA is a blind source-separation technique that has previously been used to parcellate fMRI data into spatially overlapping, but maximally independent, spatiotemporal components (28)(29)(30)(31)(32)(33)(34). We previously showed that local ICA can reliably parcellate the TPJ into spatiotemporal components, each functionally connected to distinct, brain-wide networks (32).…”

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confidence: 99%

Cortical networks involved in visual awareness independent of visual attention

Webb

Igelström

Schurger

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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It is now well established that visual attention, as measured with standard spatial attention tasks, and visual awareness, as measured by report, can be dissociated. It is possible to attend to a stimulus with no reported awareness of the stimulus. We used a behavioral paradigm in which people were aware of a stimulus in one condition and unaware of it in another condition, but the stimulus drew a similar amount of spatial attention in both conditions. The paradigm allowed us to test for brain regions active in association with awareness independent of level of attention. Participants performed the task in an MRI scanner. We looked for brain regions that were more active in the aware than the unaware trials. The largest cluster of activity was obtained in the temporoparietal junction (TPJ) bilaterally. Local independent component analysis (ICA) revealed that this activity contained three distinct, but overlapping, components: a bilateral, anterior component; a left dorsal component; and a right dorsal component. These components had brain-wide functional connectivity that partially overlapped the ventral attention network and the frontoparietal control network. In contrast, no significant activity in association with awareness was found in the banks of the intraparietal sulcus, a region connected to the dorsal attention network and traditionally associated with attention control. These results show the importance of separating awareness and attention when testing for cortical substrates. They are also consistent with a recent proposal that awareness is associated with ventral attention areas, especially in the TPJ.A major goal of the scientific study of consciousness is to understand which brain regions form the substrate of subjective awareness. This goal has often been approached by comparing the effects of a stimulus on the brain when subjects are aware vs. unaware of the stimulus. A number of elegant paradigms have been designed for this purpose, with the aim of making the stimulus as similar as possible in the two conditions (1, 2), such that any neural differences that emerge are more reasonably attributed to a difference in awareness than to a difference in the stimuli themselves. Using this approach, studies have pointed to a frontoparietal network, including the dorsolateral prefrontal cortex, the middle and inferior frontal gyri, the intraparietal sulcus, the superior parietal lobule, and a number of regions within the temporoparietal junction (TPJ) (3-9), although some questions remain regarding the specific role of each of these regions (9-11).One potential concern is the conflation of attention and awareness. During the last 15 y, it has become well established that awareness and attention can be separated. It is possible for people to attend to a visual stimulus, as measured by standard attention tasks such as the spatial Posner cuing task, while reporting no subjective awareness of the stimulus (12-15). Attention and awareness are, however, closely linked. They covary under normal conditions (16-1...

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Functional segmentation of the brain cortex using high model order group PICA

Cited by 347 publications

References 58 publications

Neural Correlates of Trial-to-Trial Fluctuations in Response Caution

Neural Correlates of Trial-to-Trial Fluctuations in Response Caution

Brain activity and connectivity during poetry composition: Toward a multidimensional model of the creative process

Cortical networks involved in visual awareness independent of visual attention

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