Andis Klegeris, Hyun B. Choi, James G. McLarnon, Patrick L. McGeer
Abstract:Ryanodine receptors (RyRs) are intracellular Ca(2+) channels that mediate the release of calcium from internal stores and therefore play an important role in Ca(2+) signaling and homeostasis. Three RyR isoforms have been described thus far, and various areas of brain are known to express each of them. It is well established that neurons can express different RyR isoforms, but it is not known whether microglial cells do so. In the present study we showed that cultured human microglia from both fetal and adult b…
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