Functional role of rat prelimbic-infralimbic cortices in spatial memory: evidence for their involvement in attention and behavioural flexibility

Delatour, Benoı̂t; Gisquet-Verrier, Pascale

doi:10.1016/s0166-4328(99)00168-0

Cited by 154 publications

(83 citation statements)

References 65 publications

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“…That is, when one of two action-outcome contingencies was degraded, animals with PL lesions suppressed responding on both responses equally. Corbit and Balleine (2003) argued that these results further support the claim that the PL is crucial for retrieval of action-outcome associations (see also Balleine and Dickinson, 1998;Killcross and Coutureau, 2003;Coutureau et al, 2009), an interpretation that is perhaps in line with the proposal that the PL has an important role in working memory (Delatour and Gisguet-Verrier, 1996, 1999, 2000Ragozzino et al, 2002;for review, see Kesner and Churchwell, 2011). The role of the PL also extends to operant reinstatement after extinction (e.g., drug-induced and cueinduced reinstatement) (for review, see Bossert et al, 2013), effects that may depend at least partly on the context (e.g., Baker et al, 1991).…”

Section: The Role Of the Pl In Operant Respondingsupporting

confidence: 59%

Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding

et al. 2017

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Operant responding in rats provides an analog to voluntary behavior in humans and is used to study maladaptive behaviors, such as overeating, drug taking, or relapse. In renewal paradigms, extinguished behavior recovers when tested outside the context where extinction was learned. Inactivation of the prelimbic (PL) region of the medial prefrontal cortex by baclofen/muscimol (B/M) during testing attenuates renewal when tested in the original acquisition context after extinction in another context (ABA renewal). Two experiments tested the hypothesis that the PL is important in context-dependent responding learned during conditioning. In the first, rats learned to lever-press for a sucrose-pellet reward.

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Section: The Role Of the Pl In Operant Respondingsupporting

confidence: 59%

Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding

et al. 2017

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“…They mobilize, in the primate and human brain, areas such as the dorsolateral prefrontal cortex, the anterior and posterior cingulate, and the posterior parietal cortex (32,33). In rats, planning and flexible behaviors also rely on prefrontal cortex integrity (21,22,(34)(35)(36). Such ''supervisory'' executive processes (37) may plausibly mobilize sets of neurons with long-range axons belonging to a global workspace.…”

Section: Discussionmentioning

confidence: 99%

Executive and social behaviors under nicotinic receptor regulation

Granon

Fauré

Changeux

2003

Proc. Natl. Acad. Sci. U.S.A.

152

164

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Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to complex cognitive functions, we developed an automated method to investigate sequential locomotor behavior in the mouse and an analysis of social behavior. We show that, in the ␤2 ؊/؊ mutant, the high-order spatiotemporal organization of locomotor behavior, together with conflict resolution and social interaction, is selectively dissociated from low-level, more automatic motor behaviors. Such deficits in executive functions resemble the rigid and asocial behavior found in some psychopathological disorders such as autism and attention deficit hyperactivity disorder. N icotine and nicotinic agonists enhance cognitive and psychomotor behaviors in various species (1-5). Conversely, nicotinic antagonists (6, 7) and loss of nicotinic acetylcholine receptors (nAChRs) under various pathological conditions impair cognitive performance (8-10). These pharmacological actions of nicotine are mediated by a variety of nAChR subtypes with different distribution patterns in the brain (11,12). To unravel their respective contribution to brain functions, mice lacking defined nAChR subunits have been generated (for a review see ref. 13).Brain nAChRs are pentameric oligomers composed of protein subunits arranged in various combinations of ␣ (2-9) and ␤ (2-4). The principal combinations that predominate in the brain are ␣4␤2 and ␣7 subunits (13,14). Mice lacking the ␤2 subunits show abnormal passive avoidance (15) and impaired nicotine self-administration (16) and drug discrimination (17) and exhibit a reduced nociceptive response to nicotine (18) and decreased visual acuity (19). On the other hand, general spatial memory tested in the water-maze task is not affected (9).The aim of this article is to explore the contribution of nAChRs to complex cognitive functions referred to as executive processes. The management of these processes provides the maintenance of goal representation, the appropriate adaptation of behavior in a changing environment, the organization of sequences of actions over time, and the inhibition of prepotent or previous responses (20). Former work in humans and animals has shown that these processes require prefrontal and͞or cingulate activation (21-24). Behavioral protocols known to rely on the integrity of these structures were adapted to mice.We developed an automated analytical procedure for locomotor behavior (25) in the mouse. This method makes possible the distinction and quantitative evaluation of high-level executive components from low-level motor behavior. Furthermore, to study an index of adapted responses to a context that potentially leads to conflict resolution, we designed a procedure aimed at the distinction between several types of sequential behaviors in a social context. Interestingly, the ''supervisory planning'' organization of mouse locomotor behavior and conflict resolution were found selectivel...

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“…Later studies revealed that mPFC lesions can also cause no impairment in spatial navigation, but rather result in a deficit of behavioural flexibility (De Bruin et al 1994, 2001Lacroix et al 2002). In various tests, it has been shown that destruction or inactivation of mPFC does not affect learning and memory per se, but impairs the animals' ability to shift strategy, or rule out inappropriate strategies when task demands are changed or environmental conditions are altered (Ragozzino et al 1999a, b;Delatour and Gisquet-Verrier 2000;Dias and Aggleton 2000;Lacroix et al 2002;Sullivan and Gratton 2002;Passetti et al 2002;Ragozzino et al 2003;Ragozzino 2007). At first sight, in relation to RE-mPFC connectivity, these reports seem contradictory to the rapid strategy shifting by RE-rats.…”

Section: Effects Of Hippocampal Versus Thalamic Lesionsmentioning

confidence: 99%

Neurotoxic lesions of the thalamic reuniens or mediodorsal nucleus in rats affect non-mnemonic aspects of watermaze learning

Weel¹,

Morris

2009

Brain Struct Funct

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Rats with bilateral neurotoxic reuniens (RE), mediodorsal (MD), hippocampal (HIPP) or sham (SH) lesions were tested in a standard watermaze task, together with unoperated rats. RE-rats and SH-controls readily learned to swim directly to a hidden platform. In contrast, MD-rats displayed a transient deficit characterized initially by thigmotaxis. Like in previous studies, HIPP-rats had long latencies throughout training and displayed more random swims than the other groups. In a memory probe test with the platform removed, SH-and RE-rats approached the correct location relatively directly but, whereas SH-controls persistently searched in the training quadrant, RE-rats switched to searching all over the pool. The MDgroup swam in loops to the platform, but then displayed persistent searching in the training quadrant. The HIPPgroup performed at chance. These distinct patterns indicate that, although their search strategies were different, REand MD-rats had acquired sufficient knowledge about the platform location and could recall information in the probe test. All groups performed well in a subsequent cue test with a visible platform, with RE-rats initially escaping faster than the SH-and HIPP-groups, and MD-rats improving from an initially poorer level of performance to control level. This indicates that there were no sensorimotor or motivational deficits associated with any of the lesions. In conclusion, while the RE and MD nuclei seem not to be critical for the learning and memory of a standard watermaze task, they may contribute to non-mnemonic strategy shifting when animals are challenged in ways that do not occur during training.

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Functional role of rat prelimbic-infralimbic cortices in spatial memory: evidence for their involvement in attention and behavioural flexibility

Cited by 154 publications

References 65 publications

Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding

Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding

Executive and social behaviors under nicotinic receptor regulation

Neurotoxic lesions of the thalamic reuniens or mediodorsal nucleus in rats affect non-mnemonic aspects of watermaze learning

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