Renata I. Dmitrieva, Alla V. Revittser, Maria A. Klukina, Yuri V. Sviryaev, Ludmila S. Korostovtseva, Anna A. Kostareva, Andrey Yu. Zaritskey, Evgeny V. Shlyakhto
Abstract:Background: Bone marrow multipotent mesenchymal stromal cells (BM-MMSC) considered as a prospective substrate for cell therapy applications, however adult stem cells could be affected by donor-specific factors: age, gender, medical history. Our aim was to investigate how HF affects the functional properties of BM-MMSC. Materials and methods: BM-MMSC from 10 healthy donors (HD), and 16 donors with chronic HF were evaluated for proliferative activity, ability to differentiate, replicative senescence, expression …
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