Functional polyethersulfone particles for the removal of bilirubin

Jiang, Xin; Xiang, Tao; Xie, Yi; Wang, Rui; Zhao, Weifeng; Sun, Shudong; Zhao, Changsheng

doi:10.1007/s10856-015-5642-9

Cited by 28 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Related linear relationships were proposed recently [38]: H V ¼ 0.1475G and H V ¼ 0.0607Y. Our numerical estimations reveal that the examined 122 phases will exhibit moderate hardness (of about 9e14 GPa), which is comparable with H V for their nearest 1111-like analogs: ZrCuSiAs, HfCuSiAs, ZrCuGeAs, and HfCuGeAs [25].…”

Section: Elastic Propertiessupporting

confidence: 78%

Structural, elastic and electronic properties of new layered superconductor HfCuGe2 in comparison with isostructural HfCuSi2, ZrCuGe2, and ZrCuSi2 from first-principles calculations

et al. 2013

View full text Add to dashboard Cite

Section: Elastic Propertiessupporting

confidence: 78%

Structural, elastic and electronic properties of new layered superconductor HfCuGe2 in comparison with isostructural HfCuSi2, ZrCuGe2, and ZrCuSi2 from first-principles calculations

et al. 2013

View full text Add to dashboard Cite

“…21d). Bilirubin, one of the breakdown products of red blood cell degradation, is a typical toxin in the blood, and the effective clearance of bilirubin is important for the detoxification of blood 59 . Compared with existing bilirubin adsorbents, this biocompatible membrane is advantageous for bilirubin removal due to its short diffusion path, low pressure drop and simple scaled-up process.…”

Section: Resultsmentioning

confidence: 99%

Self-assembled membrane composed of amyloid-like proteins for efficient size-selective molecular separation and dialysis

Yang

Tao

et al. 2018

Nat Commun

View full text Add to dashboard Cite

The design and scalable construction of robust ultrathin protein membranes with tunable separation properties remain a key challenge in chemistry and materials science. Here, we report a macroscopic ultrathin protein membrane with the potential for scaled-up fabrication and excellent separation efficiency. This membrane, which is formed by fast amyloid-like lysozyme aggregation at air/water interface, has a controllable thickness that can be tuned to 30–250 nm and pores with a mean size that can be tailored from 1.8 to 3.2 nm by the protein concentration. This membrane can retain > 3 nm molecules and particles while permitting the transport of small molecules at a rate that is 1~4 orders of magnitude faster than the rate of existing materials. This membrane further exhibits excellent hemodialysis performance, especially for the removal of middle-molecular-weight uremic toxins, which is 5~6 times higher in the clearance per unit area than the typical literature values reported to date.

show abstract

“…31 Binding capacities reported for polysulfone ester anion exchanging nanoparticles were ~ 5-10 times lower in comparable conditions, despite requiring binding times well above 60 minutes (see also ESI, Table S2). 32 As a second clinically relevant case, we investigated the removal of heparin. The need to anticoagulate the blood (or plasma) bears a high risk for haemorrhagic complications.…”

Section: Resultsmentioning

confidence: 99%

Tailoring the Colloidal Stability, Magnetic Separability, and Cytocompatibility of High-Capacity Magnetic Anion Exchangers

Gschwend

Matter

Keevend

et al. 2019

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Extracorporeal blood purification has been applied to artificially support kidney or liver function. However, convection and diffusion based blood purification systems have limited removal rates for high molecular weight and hydrophobic molecules. This limitation is due to the finite volume of infusion and limited membrane permeability, respectively. Adsorption provides an attractive alternative for the removal of higher molecular weight compounds. The use of adsorption resins containing ion exchanging groups to capture specific molecules has become well-established. Instead of stationary adsorption resins, however, ion exchanging polymers may be immobilized on magnetic particles and serve as freely diffusing, mobile, high capacity solid phase of ion exchange chromatography. While small beads with high surface area are attractive in terms of mass transfer and binding, unifying high capturing capacity with rapid and quantitative bead recovery remains an issue. Therefore, most of the current magnetic ion exchangers are based on micron-sized beads or require long times to separate. In addition to unfavourable magnetic recovery rates, the usually poor cytocompatibility limits their applicability in biomedicine. Here, we report on the synthesis and performance of polycationic polymer coated magnetic nanoflowers (MNF) for highly efficacious anion capturing. We demonstrate accurate control over the polymer content and composition on the beads, and show its direct influence on colloidal stability, capturing capacity and magnetic separability. We present the removal of clinically relevant targets by capturing bilirubin with capacities twofold higher than previous work as well as quantitative heparin removal. Additionally, we illustrate how copolymerization of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) with poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) leads to improved cytocompatibility of the polymer-coated MNF capturing agents while retaining high capturing capacities. Taken together, we present a nanoparticle/polymer material, which upon future in vivo validation, unifies high binding capacities and magnetic separability for rapid toxin capturing and hence fulfils key requirements of clinical utility.

show abstract

Functional polyethersulfone particles for the removal of bilirubin

Cited by 28 publications

References 47 publications

Structural, elastic and electronic properties of new layered superconductor HfCuGe2 in comparison with isostructural HfCuSi2, ZrCuGe2, and ZrCuSi2 from first-principles calculations

Structural, elastic and electronic properties of new layered superconductor HfCuGe2 in comparison with isostructural HfCuSi2, ZrCuGe2, and ZrCuSi2 from first-principles calculations

Self-assembled membrane composed of amyloid-like proteins for efficient size-selective molecular separation and dialysis

Tailoring the Colloidal Stability, Magnetic Separability, and Cytocompatibility of High-Capacity Magnetic Anion Exchangers

Contact Info

Product

Resources

About