Functional Performance of Chitosan/Carbopol 974P NF Matrices in Captopril Tablets

Abstract

Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine (NH3+) group of chitosan and the carboxylate (COO−) group of Carbopol. In situ polyelectrolyte complexes formations based on the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The aim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could modify their technological performance in captopril tablets. The drug and excipients were evaluated as mixtures of powders and tablets. The mixtures with captopril contained Carbopol 974P NF, chitosan, or a 1 : 1 mixture thereof with polymer proportions of 10%, 20%, and 30%. The evaluated parameters were the powder flow rate, the powder compressibility index, and the compactibility and release behavior of the tablets. The observed technological behavior points out to a greater interaction between the particles of polymers with different charge than between particles of the individual polymers. This produces more coherent matrices restricting more efficiently the drug dissolution, more coherent tablets with higher compactibility, and less flowing powder mixtures. All this, however, requires additional investigation to confirm the current results.

Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery

“…Therefore, if we need to release drugs directed to macrophages, we must load them within NPs_SDS, while if we would like to avoid this uptake, it is necessary to consider NPs_CC. At pH = 5, AC6 network is neutral [40], and so NPs are not able to escape due to their diameter, which is bigger with respect to the mean mesh size of AC6 hydrogel (data on AC structural parameters in Supplementary Table S2).…”

Characterizations of Swelling Granule of Clove Leaf (Syzygium aromaticum L.) Ethanol Extract

“…It is evident here that the use of HPMC, whether alone or in combination with Carbopol, significantly reduces its compressibility. The compressive strength of granules into tablets has indeed been reported to increase with the use of Carbopol (11). Carbopol itself is commonly employed in direct compression tablets (12).…”

Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review

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