Functional network connectivity in the behavioral variant of frontotemporal dementia

Filippi, Massimo; Agosta, Federica; Scola, Elisa; Canu, Elisa; Magnani, Giuseppe; Marcone, Alessandra; Valsasina, Paola; Caso, Francesca; Copetti, Massimiliano; Comı, Gıancarlo; Cappa, Stefano F.; Falini, Andrea

doi:10.1016/j.cortex.2012.09.017

Cited by 161 publications

(169 citation statements)

References 78 publications

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“…Previous studies have reported similar alterations in bvFTD and reported that less grey matter volume of the thalamus might be associated with the loss of the ability of processing social and emotional information (Krueger et al, 2010;Rosen, 2005;Seeley et al, 2009). These results are in line with a previous structural covariance study that reported that the thalamus, a key area of the 'Salience' network (SN), showed less activity in functional network studies among bvFTD subjects de Haan et al, 2009;Filippi et al, 2013;Hafkemeijer et al, 2016;Zhou et al, 2010). Possibly, the loss of function of this area is associated with structural alterations in bvFTD supporting the hypothesis that clinical symptoms, functional and structural alterations are closely related.…”

Section: Discussionsupporting

confidence: 81%

“…A few studies have compared grey matter networks between bvFTD and AD patients (Hafkemeijer et al, 2016;Seeley et al, 2009) and have illustrated that these disorders show anatomically distinct grey matter networks, which suggests that bvFTD pathology targets different networks than Alzheimer's disease pathology. In line with these findings, studies using a functional network approach suggest that brain networks might alter in a disease specific way: In AD, a more 'random' network and less activity in default mode network (DMN) has been described, while bvFTD has a more 'ordered' network and less activity in the Salience network (SN) (de Haan et al, 2009;Filippi et al, 2013;Hafkemeijer et al, 2015;Stam et al, 2007;Zhou and Seeley, 2015). Such 'random' networks show lower values of clustering and path length, while 'ordered' networks show higher values for those properties.…”

Section: Introductionmentioning

confidence: 83%

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Gray matter network differences between behavioral variant frontotemporal dementia and Alzheimer's disease

Vijverberg

Tijms

Dopp

et al. 2017

Neurobiology of Aging

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We set out to study whether single-subject grey matter (GM) networks show disturbances that are specific for Alzheimer's disease (AD) (n=90) or behavioral variant Frontotemporal dementia (bvFTD) (n=59), and whether such disturbances would be related to cognitive deficits measured with Mini-mental state examination (MMSE) and a neuropsychological battery, using subjective cognitive decline subjects (SCD) as reference. AD and bvFTD patients had a lower degree, connectivity density, clustering, path length, betweenness centrality and small world values compared to SCD. AD patients had a lower connectivity density than bvFTD patients (F = 5.79, p = 0.02; Mean±SD bvFTD 16.10% ± 1.19; Mean±SD AD 15.64% ± 1.02). Lasso logistic regression showed that connectivity differences between bvFTD and AD were specific to 23 anatomical areas, in terms of local GM volume, degree and clustering. Lower clustering values and lower degree values were specifically associated with worse MMSE scores and lower performance on the neuropsychological tests. GM showed disease-specific alterations, when comparing bvFTD with AD patients, and these alterations were associated with cognitive deficits.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 83%

Gray matter network differences between behavioral variant frontotemporal dementia and Alzheimer's disease

Vijverberg

Tijms

Dopp

et al. 2017

Neurobiology of Aging

View full text Add to dashboard Cite

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“…Thus, in bvFTD the apparent empathy deficits might be more due to the failure of taking an affective perspective instead of action observation deficits, per se. The deficits in anterior cingulate/vMPFC associated with loss of empathy in bvFTD are of particular interest for ALS, where patients show consistently changes in anterior cingulate regions as well (Lillo et al , 2012, Filippi et al , 2013. Indeed, recent studies suggest that impairments of emotional decision-making, and impaired empathy might be also more due to anterior cingulate and insula atrophy changes than ventral motor cortex atrophy in ALS (Girardi et al , 2011, Cerami et al , 2014.…”

Section: A Role In Empathymentioning

confidence: 99%

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Eisen

Lemon

Kiernan

et al. 2015

Clinical Neurophysiology

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Eisen et al, Mirror Neurons in ALS 2 Declaration of interest:The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. Eisen et al, Mirror Neurons in ALS 3 Abbreviations:ALS: Amyotrophic lateral sclerosis; ADM: adductor digiti minimi; APB: abductor pollicic brevis; bvFTD: Behavioral variant of frontotemporal dementia; FTD: Frontotemporal dementia; fMRI: functional MRI; MNS: Mirror neuron system; M1: Primary motor cortex; PTNs: Pyramidal tract neurons; vMPFC: Ventral medial prefrontal cortex. Eisen et al, Mirror Neurons in ALS 4 AbstractThere is growing evidence that mirror neurons, initially discovered over two decades ago in the monkey, are present in the human brain. In the monkey, mirror neurons characteristically fire not only when it is performing an action, such as grasping an object, but also when observing a similar action performed by another agent (human or monkey). In this review we discuss the origin, cortical distribution and possible functions of mirror neurons as a background to exploring their potential relevance in amyotrophic lateral sclerosis (ALS). We have recently proposed that ALS (and the related condition of frontotemporal dementia) may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations. The mirror neuron system is considered by many to be the basis of primates' social cognition, with a clear evolutionary advantage. Impaired empathy and motor control has been related to a defective mirror neuron system. In ALS, the mirror neuron system might be implicated in empathy, the split-hand syndrome, gait, speech, and related languagegesture impairments.Eisen et al, Mirror Neurons in ALS 5

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“…We have previously reported increased connectivity in the left DAN in a patient group that consisted of both sporadic and genetically confirmed bvFTD [17]. However, Filippi with colleagues did not find any changes in the DAN and there are no other reports available [14].…”

Section: Discussionmentioning

confidence: 86%

“…However, decreased functional connectivity in the salience network has been the most frequent finding in bvFTD. In some studies increased connectivity in the DMN has been observed, but there has been a lot of variation concerning the DMN related findings in bvFTD [12,14,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Functional MRI in Patients with the C9ORF72 Expansion associate Frontotemporal Dementia

Rytty¹,

Nikkinen²,

Noora³

et al. 2014

Mol Biol

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Functional MRI studies have revealed connectivity changes in several brain networks in patients with neurodegenerative diseases and imaging genomics is an emerging field to investigate the role of genetics in brain function. A hexanucleotide repeat expansion in open reading frame in chromosome 9 (C9ORF72) is a common cause of familial frontotemporal dementia. The aim of this study was to evaluate resting state networks in behavioral variant frontotemporal dementia (bvFTD) patients with the C9ORF72 expansion by using functional MRI. Seven patients and matched healthy controls were examined. The group specific resting state networks were identified by independent component analysis and the dual regression technique was used to detect between-group differences in the resting state networks with p<0.05 threshold corrected for multiple comparisons. Increased anti-correlation between bilateral thalamic parts of the salience network and anterior sub-network of the Default mode network (DMN) was found in patients with the C9ORF72 expansion. In addition, increased resting state connectivity was detected in the right-sided dorsal attention network. The changes in these cognitive networks may explain executive dysfunction as well as neuropsychiatric symptoms in patients with bvFTD.

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Functional network connectivity in the behavioral variant of frontotemporal dementia

Cited by 161 publications

References 78 publications

Gray matter network differences between behavioral variant frontotemporal dementia and Alzheimer's disease

Gray matter network differences between behavioral variant frontotemporal dementia and Alzheimer's disease

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Functional MRI in Patients with the C9ORF72 Expansion associate Frontotemporal Dementia

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