Functional Nanomaterials for Phototherapies of Cancer

Abstract

Figure 17. Optimization of graphene-based photothermal agents. (a) AFM images of different graphene derivatives: while nGO-PEG and nRGO-PEG showed similar ultrasmall sizes at about 20−30 nm, the size of RGO-PEG was about 60−70 nm. Insets are photos of the respective solutions. RGO-PEG and nRGO-PEG showed much enhanced optical absorbance as compared to nGO-PEG. (b) The blood circulation of GO derivatives measured by collecting blood from mice iv injected with 125 I labeled nGO-PEG, nRGO-PEG, and RGO-PEG at various time points (n = 3). (c) The biodistribution of GO derivatives in 4T1 tumor-bearing mice 2 days after injection. The radioactivities in tissue and blood samples were determined by a gamma counter. (d) The 4T1 tumor growth curves of mice after various treatments indicated. The laser irradiation was conducted at the power density of 0.15 W/cm 2 for 5 min. (e) Survival of tumor-bearing mice after various treatments indicated. Reprinted with permission from ref 169.

Synthesis and Optimization of MoS2@Fe3O4‐ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser

“…Chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) are three main types of cancer treatment methods, which have achieved great success in extending the lives of cancer patients 1, 2, 3, 4, 5, 6, 7. However, the monotherapy, though maximally optimized, generally cannot eradicate the malignant tumors completely owning to the serious metastasis of cancer and the development of drug resistance 8, 9, 10.…”

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

“…However, to the best of our knowledge, the therapeutic strategies for TNBC on previous studies are lack of imaging guidance. For photothermal‐chemical combination therapy of TNBC, imaging‐guided therapy has several advantages to improve the therapeutic efficacy 17, 18, 19, 20, 21, 22, 23, 24, 25. First, imaging could provide the information of the tumor's shape, size, location, and relationship with surrounding tissues, which is helpful for determining treatment position and scope.…”

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

“…In addition to carry bioactive compounds, gold nanoparticles can be applied for cancer photothermal therapy (PTT), as it can efficiently convert absorbed light to heat to destroy adjacent cancer cells without the destruction of surrounding normal and healthy tissues 104. By changing the thickness of the core and shell of gold nanostructures, the peak of localized surface plasma resonance can be shifted to the near‐infrared radiation (NIR) region, which is beneficial for tumor treatment, as NIR light demonstrates deeper light penetration in tissues than the light with wavelength below 700 nm.…”