Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors

Zacharia, Thomas; Eslinger, Paul J.

doi:10.1002/ca.23439

Cited by 16 publications

(14 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same principle of precise temporal coordination can here be applied to the phase alignment of neuronal oscillations to optimize coherence and thus cerebral cortical communication in any task dependent manner. Such a role in modulating the communication between cerebral cortical areas would engage the cerebellum in almost any task involving the cerebral cortex and could explain why functional imaging studies reliably detect activation of the cerebellum in a broad range of sensorimotor and cognitive tasks (Zacharia and Eslinger, 2019). Our findings in the cognitive domain and those of others in sensorimotor context strongly suggest the possibility that the cerebellum has a role in coordinating communication through coherence between cerebral cortical areas.…”

Section: Discussionsupporting

confidence: 51%

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

Liu

McAfee

Heijden

et al. 2020

Preprint

View full text Add to dashboard Cite

Spatial working memory (SWM) in rodents jointly requires the medial prefrontal cortex (mPFC) and dorsal hippocampal CA1 region (dCA1). We show that the decision-making process in a SWM task is associated with increased coherence of gamma oscillations between the mPFC and dCA1, with the magnitude of coherence change correlated with decision outcome. Purkinje cells in the cerebellar lobulus simplex (LS) have been shown to represent mPFC and dCA1 gamma oscillation phase and phase differences. Here we show that the LS is causally involved in the modulation of decision-related mPFC-dCA1 gamma coherence and SWM performance. Previous studies reported a cerebellar involvement in modulating coherence between sensory and motor cortical areas. Together these findings suggest cerebellar modulation of cerebral cortical coherence as a possible universal mechanism of cerebrocerebellar interaction.

show abstract

Section: Discussionsupporting

confidence: 51%

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

Liu

McAfee

Heijden

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“… 60–63 Radiological evidence of cross-cerebellar diaschisis, the presence of the pulvinar sign 63 and brain atrophy 64 were indicative of prolonged seizure activity and favoured a particular pattern of seizure spread, including involvement of cortico-ponto-cerebellar pathways. 65 …”

Section: Discussionmentioning

confidence: 99%

Forecasting stroke-like episodes and outcomes in mitochondrial disease

Lax

Blain

et al. 2021

Brain

View full text Add to dashboard Cite

In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes and to identify associated risk predictors. Between January 1998 and June 2018, we identified 111 patients with genetically-determined mitochondrial disease who developed stroke-like episodes. Post-mortem cases of mitochondrial disease (n = 26) were identified from Newcastle Brain Tissue Resource. The primary outcome was to interrogate the clinic-radio-pathological correlates and prognostic indicators of stroke-like episode in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome. The secondary objective was to develop a multivariable prediction model to forecast stroke-like episode risk. The most common genetic cause of stroke-like episodes was the m.3243A>G variant in MT-TL1 (n = 66), followed by recessive pathogenic POLG variants (n = 22), and 11 other rarer pathogenic mitochondrial DNA (mtDNA) variants (n = 23). The age of first stroke-like episode was available for 105 patients (mean [SD] age: 31.8 [16.1]); a total of 35 patients (32%) presented with their first stroke-like episode ≥40 years of age. The median interval (interquartile range) between first and second stroke-like episodes was 1.33 (2.86) years; 43% of patients developed recurrent stroke-like episodes within 12 months. Clinico-radiological, electrophysiological and neuropathological findings of stroke-like episodes were consistent with the hallmarks of medically refractory epilepsy. Patients with POLG-related stroke-like episodes demonstrated more fulminant disease trajectories than cases of m.3243A>G and other mtDNA pathogenic variants, in terms of the frequency of refractory status epilepticus, rapidity of progression and overall mortality. In multivariate analysis, baseline factors of body mass index, age-adjusted blood m.3243A>G heteroplasmy, sensorineural hearing loss and serum lactate were significantly associated with risk of stroke-like episodes in patients with the m.3243A>G variant. These factors informed the development of a prediction model to assess the risk of developing stroke-like episodes that demonstrated good overall discrimination (area under the curve = 0.87, 95% CI 0.82–0.93; c-statistic = 0.89). Significant radiological and pathological features of neurodegeneration was more evident in patients harbouring pathogenic mtDNA variants compared with POLG: brain atrophy on cranial MRI (90% vs 44%, p < 0.001) and reduced mean brain weight [SD] (1044 g [148] vs 1304 g [142], p = 0.005). Our findings highlight the often idiosyncratic clinical, radiological and EEG characteristics of mitochondrial stroke-like episodes. Early recognition of seizures and aggressive instigation of treatment may help circumvent or slow neuronal loss and abate increasing disease burden. The risk-prediction model for the m.3243A>G variant can help inform more tailored genetic counselling and prognostication in routine clinical practice.

show abstract

“…However, increasing evidence has demonstrated that the cerebellum also plays an important role in cognitive processing, and memory and executive functions are mostly localized in the posterior cerebellum (E et al, 2014), which is supported by many researchers. Functional MRI evidence found cerebellar activation is a consistent finding with memory tasks predominantly in the posterior lobe of the cerebellum (Zacharia and Eslinger, 2019). Schmahmann found that lesions of the posterior lobe of the cerebellum were particularly important in impairments in executive function (Zhuang et al, 2017;Schmahmann, 2019).…”

Section: Discussionmentioning

confidence: 70%

The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities

Cao

Nie

Zhang

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

ObjectiveWhite matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is frequently presumed to be secondary to cerebral small vessel disease (CSVD) and associated with cognitive decline. The cerebellum plays a key role in cognition and has dense connections with other brain regions. Thus, the aim of this study was to investigate if cerebellar abnormalities could occur in CSVD patients with WMHs and the possible association with cognitive performances.MethodsA total of 104 right-handed patients with WMHs were divided into the mild WMHs group (n = 39), moderate WMHs group (n = 37), and severe WMHs group (n = 28) according to the Fazekas scale, and 36 healthy controls were matched for sex ratio, age, education years, and acquired resting-state functional MRI. Analysis of voxel-based morphometry of gray matter volume (GMV) and seed-to-whole-brain functional connectivity (FC) was performed from the perspective of the cerebellum, and their correlations with neuropsychological variables were explored.ResultsThe analysis revealed a lower GMV in the bilateral cerebellum lobule VI and decreased FC between the left- and right-sided cerebellar lobule VI with the left anterior cingulate gyri in CSVD patients with WMHs. Both changes in structure and function were correlated with cognitive impairment in patients with WMHs.ConclusionOur study revealed damaged GMV and FC in the cerebellum associated with cognitive impairment. This indicates that the cerebellum may play a key role in the modulation of cognitive function in CSVD patients with WMHs.

show abstract

Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors

Cited by 16 publications

References 43 publications

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

Forecasting stroke-like episodes and outcomes in mitochondrial disease

The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities

Contact Info

Product

Resources

About