Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn’s disease versus healthy controls

Agostini, Alessandro; Filippini, Nicola; Benuzzi, Francesca; Bertani, A.; Scarcelli, A.; Leoni, Chiara; Farinelli, Valentina; Riso, Donatella; Tambasco, Rosy; Calabrese, Carlo; Rizzello, Fernando; Gionchetti, Paolo; Ercolani, Mauro; Nichelli, Paolo Frigio; Campieri, Massimo

doi:10.1007/s10865-012-9441-1

Cited by 54 publications

(51 citation statements)

References 30 publications

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“…These results also indicate decreased coupling between the cortex and subcortical regions and were consistent with the imaging results in this study. A previous study also showed that CD patients have abnormal neural activity in the amygdala, hippocampus, insula, putamen, cerebellar regions when performing stress-evoking tasks, suggesting altered habituation to stress in these patients32. Structurally, CD patients were found to exhibit decreased GM volumes in the frontal and the anterior midcingulate cortex17.…”

Section: Discussionmentioning

confidence: 89%

Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease

Bao

Liu

et al. 2016

Sci Rep

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This study aimed to investigate changes in resting state brain activity in remissive Crohn’s Disease (CD) patients after electro-acupuncture or moxibustion treatment. Fifty-two CD patients and 36 healthy subjects were enrolled, and 36 patients were equally and randomly assigned to receive either electro-acupuncture or moxibustion treatment for twelve weeks. We used resting state functional magnetic resonance imaging to assess Regional Homogeneity (ReHo) levels, and Crohn’s Disease Activity Index (CDAI) and Inflammatory Bowel Disease Questionnaire (IBDQ) scores to evaluate disease severity and quality of life. The results show that (i) The ReHo levels in CD patients were significantly increased in cortical but decreased in subcortical areas, and the coupling between them was declined. (ii) Both treatments decreased CDAI, increased IBDQ scores, and normalized the ReHo values of the cortical and subcortical regions. (iii) ReHo changes in multiple cortical regions were significantly correlated with CDAI score decreases. ReHo changes in several subcortical regions in the electro-acupuncture group, and those of several cortical regions in the moxibustion group, were correlated with reduced CDAI. These findings suggest that both treatments improved cortex-subcortical coupling in remissive CD patients, but electro-acupuncture regulated homeostatic afferent processing network, while moxibustion mainly regulated the default mode network of the brain.

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Section: Discussionmentioning

confidence: 89%

Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease

Bao

Liu

et al. 2016

Sci Rep

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show abstract

“…Previous studies show alternations in gray matter (GM) structures including GM volumes and cortical thickness in multiple brain regions of CD patients, which in certain brain regions are correlated with disease duration [1, 6]. CD patients also have been found to exhibit altered habituation to stress and altered neural activity in the amygdala, hippocampus, insula, putamen, and cerebellar regions when performing stress-evoking tasks [2]. However, to date, there has been no study on resting-state brain activity in CD patients.…”

Section: Introductionmentioning

confidence: 99%

Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging

Bao

Liu

et al. 2016

Pain

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Abnormal pain processing in the central nervous system may be related to abdominal pain in patients with Crohn's disease (CD). The purpose of this study was to investigate changes in resting-state brain activity in CD patients in remission and its relationship with the presence of abdominal pain. Twenty-five CD patients with abdominal pain, 25 CD patients without abdominal pain, and 32 healthy subjects were scanned using a 3.0 T functional magnetic resonance imaging (fMRI) scanner. Regional homogeneity (ReHo) was used to assess resting-state brain activity. Daily pain scores were collected 1 week before fMRI scanning. We found that patients with abdominal pain exhibited lower ReHo values in the insula, middle cingulate cortex (MCC), and supplementary motor area, and higher ReHo values in the temporal pole. In contrast, patients without abdominal pain exhibited lower ReHo values in the hippocampal/parahippocampal cortex and higher ReHo values in the dorsomedial prefrontal cortex (all P<0.05, corrected). The ReHo values of the insula and MCC were significantly negatively correlated with daily pain scores for patients with abdominal pain (r=−0.53, P=0.008, and r=−0.61, P=0.002, respectively). These findings suggest that resting-state brain activities are different between remissive CD patients with and without abdominal pain, and that abnormal activities in insula and MCC are closely related to the severity of abdominal pain.

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“…Rs-fMRI analytical methods include regional homogeneity (ReHo)[34], functional connectivity (FC)[35] and amplitude of low-frequency fluctuation (ALFF)[36]. Using fMRI, Agostini et al[37] and Bao et al[38] found abnormal functional activity in the cerebral cortex of patients with CD (Table 1). …”

Section: Bold-fmri For Detecton Of Brain Changes In CDmentioning

confidence: 99%

“…Agostini et al[37] hypothesized inadequate habituation to stress as a characteristic for CD patients, and their study sought to compare neural habituation between CD patients and healthy subjects. During a high-stress task, different neural regions were activated between the two groups.…”

Section: Bold-fmri For Detecton Of Brain Changes In CDmentioning

confidence: 99%

“…BOLD-fMRI studies have confirmed changes in local cerebral blood oxygen concentrations in patients with CD. Based on previous observations[37,38], it is hypothesized that metabolites of functional brain areas will be changed accordingly in patients with CD. Specifically, the excitatory and inhibitory neurotransmitters associated with mental and psychological factors such as Glu and GABA[51,52], respectively, are thought to vary.…”

Section: Clinical Applications Of Mrs and Future Directionsmentioning

confidence: 99%

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Brain changes detected by functional magnetic resonance imaging and spectroscopy in patients with Crohn's disease

Lv¹,

Fan²,

Xu³

et al. 2017

WJG

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Crohn’s disease (CD) is a chronic, non-specific granulomatous inflammatory disorder that commonly affects the small intestine and is a phenotype of inflammatory bowel disease (IBD). CD is prone to relapse, and its incidence displays a persistent increase in developing countries. However, the pathogenesis of CD is poorly understood, with some studies emphasizing the link between CD and the intestinal microbiota. Specifically, studies point to the brain-gut-enteric microbiota axis as a key player in the occurrence and development of CD. Furthermore, investigations have shown white-matter lesions and neurologic deficits in patients with IBD. Based on these findings, brain activity changes in CD patients have been detected by blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI). BOLD-fMRI functions by detecting a local increase in relative blood oxygenation that results from neurotransmitter activity and thus reflects local neuronal firing rates. Therefore, biochemical concentrations of neurotransmitters or metabolites may change in corresponding brain regions of CD patients. To further study this phenomenon, brain changes of CD patients can be detected non-invasively, effectively and accurately by BOLD-fMRI combined with magnetic resonance spectroscopy (MRS). This approach can further shed light on the mechanisms of the occurrence and development of neurological CD. Overall, this paper reviews the current status and prospects on fMRI and MRS for evaluation of patients with CD based on the brain-gut-enteric microbiota axis.

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Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn’s disease versus healthy controls

Cited by 54 publications

References 30 publications

Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease

Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease

Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging

Brain changes detected by functional magnetic resonance imaging and spectroscopy in patients with Crohn's disease

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