Functional Layered Double Hydroxide Nanohybrids for Biomedical Imaging

Abstract

Biomedical investigations using layered double hydroxide (LDH) nanoparticles have attracted tremendous attentions due to their advantages such as biocompatibility, variable-chemical compositions, anion-exchange capacity, host–guest interactions, and crystallization-dissolution characters. Bio-imaging becomes more and more important since it allows theranostics to combine therapy and diagnosis, which is a concept of next-generation medicine. Based on the unique features mentioned above, LDHs create novel opportunities for bio-imaging and simultaneous therapy with LDHs-based nanohybrids. This review aims to explore the recent advances in multifunctional LDH nanohybrids ranging from synthesis to practical applications for various bio-imaging with therapeutic functions. Furthermore, their potential both as diagnostic agents and drug delivery carriers will be discussed with the improvement in noninvasive bio-imaging techniques.

Niclosamide-Exfoliated Anionic Clay Nanohybrid Repurposed as an Antiviral Drug for Tackling Covid-19; Oral Formulation with Tween 60/Eudragit S100

“…Among the various drug carriers that have been tried, inorganic materials such as exfoliated layered double hydroxides (X-LDH) play a vital role because of their excellent biocompatibility and biodegradability (Choi, 2018b;Choi et al, 2021b;. LDH-based hybrid NPs have been used widely, therefore, particularly for drug delivery (Yan et al, 2019), bio-imaging (Jin & Park, 2019), and tissue engineering (Belgheisi et al, 2020).…”

Synthesis and Cytotoxicity Study of Magnetite Nanoparticles Coated with Polyethylene Glycol and Sorafenib–Zinc/Aluminium Layered Double Hydroxide

“…The targeted delivery of chemotherapeutic agents to cancer cells by SPIONs has been studied and has showed promising results that anticancer drug loading on the surface of SPIONs can enhance drug performance and quick removal from the bloodstream [ 19 , 20 ]. Nonetheless, the chemical instability of SPIONs and the agglomeration of particles are challenging [ 21 ]. Thus, the development of effective approaches for the enhancement of the chemical stability of SPIONs is of great importance.…”

Confined Growth of NiAl-Layered Double Hydroxide Nanoparticles Within Alginate Gel: Influence on Electrochemical Properties

“…Based on fine control of the synthesis conditions, matrices with a tunable chemical composition are prepared by varying the nature of M 2+ and M 3+ , their ratio and the type of anion intercalated which can range from simple inorganic anions, polyoxometalates (Liu et al, 2020 ) and organic or even bioorganic anions bearing carboxylate, sulfonate, or phosphonate groups (Taviot-Guého et al, 2018 ). Thanks to their unique properties, LDH are emerging as an important class of layered materials with potential applications as adsorbents in water treatment (Zhang R. et al, 2020 ), nuclear waste storage materials (Gu et al, 2018 ), electro-photo-catalysts for organic molecule conversion (Fan et al, 2014 ; Xu and Wei, 2018 ; Cai et al, 2019 ; Liu et al, 2020 ) or pollutant degradation (Zhang G. et al, 2020 ), energy storage and conversion (Patel et al, 2018 ; Cai et al, 2019 ; Xie et al, 2019 ; Yang et al, 2019 ), electrode materials for detection (Mousty and Prévot, 2013 ) and biocompatible inorganic matrices for drug delivery system development (Choi et al, 2018a , b ) or biomedical imaging (Jin and Park, 2019 ).…”