Functional knee assessment with advanced imaging

Amano, Keiko; Li, Qi; Benjamin, C.

doi:10.1007/s12178-016-9340-0

Cited by 11 publications

(8 citation statements)

References 60 publications

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“…Additionally, individuals with cruciate ligament degeneration present with greater severity of cartilage damage, bone marrow lesions, subchondral cysts, and lateral meniscus pathology when compared to individuals with normal cruciate ligaments [33]. While we are unable to make definitive claims based on our results, cruciate ligament degeneration could be early evidence of a maladaptation to loading or due to aberrant joint loading created by impaired ligamentous function that increases knee instability or laxity [34]. Future studies are needed to confirm whether the presence of knee instability increases the risk for incident AKOA.…”

Section: Discussionmentioning

confidence: 99%

Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Harkey

Davis

Lü

et al. 2019

BMC Musculoskelet Disord

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Background Accelerated knee osteoarthritis (AKOA) is characterized by more pain, impaired physical function, and greater likelihood to receive a joint replacement compared to individuals who develop the typical gradual onset of disease. Prognostic tools are needed to determine which structural pathologies precede the development of AKOA compared to individuals without AKOA. Therefore, the purpose of this manuscript was to determine which pre-radiographic structural features precede the development of AKOA. Methods The sample comprised participants in the Osteoarthritis Initiative (OAI) who had at least one radiographically normal knee at baseline (Kellgren-Lawrence [KL] grade < 1). Participants were classified into 2 groups based on radiographic progression from baseline to 48 months: AKOA (KL grade change from < 1 to > 3) and No AKOA. The index visit was the study visit when participants met criteria for AKOA or a matched timepoint for those who did not develop AKOA. Magnetic resonance (MR) images were assessed for 12 structural features at the OAI baseline, and 1 and 2 years prior to the index visit. Separate logistic regression models (i.e. OAI baseline, 1 and 2 years prior) were used to determine which pre-radiographic structural features were more likely to antedate the development of AKOA compared to individuals not developing AKOA. Results At the OAI baseline visit, degenerative cruciate ligaments (Odds Ratio [OR] = 2.2, 95% Confidence Interval [CI] = 1.3,3.5), infrapatellar fat pad signal intensity alteration (OR = 2.0, 95%CI = 1.2,3.2), medial/lateral meniscal pathology (OR = 2.1/2.4, 95%CI = 1.3,3.4/1.5,3.8), and greater quantitative knee effusion-synovitis (OR = 2.2, 95%CI = 1.4,3.4) were more likely to antedate the development of AKOA when compared to those that did not develop AKOA. These results were similar at one and two years prior to disease onset. Additionally, medial meniscus extrusion at one year prior to disease onset (OR = 3.5, 95%CI = 2.1,6.0) increased the likelihood of developing AKOA. Conclusions Early ligamentous degeneration, effusion/synovitis, and meniscal pathology precede the onset of AKOA and may be prognostic biomarkers.

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Section: Discussionmentioning

confidence: 99%

Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Harkey

Davis

Lü

et al. 2019

BMC Musculoskelet Disord

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“…Moreover, this study used static loaded MRI, which is not a complete true representation of walking or other more complex motions . However, it is very difficult to take accurate motion MRI measurements due to decreased resolution . Instead, we scanned the knees at extension to capture them at midstance with loading in attempt to simulate the natural weight bearing aspect of walking.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal analysis of tibiofemoral cartilage contact area and position in ACL reconstructed patients

Chen

Amano

Pedoia

et al. 2018

Journal Orthopaedic Research

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Patients who have suffered ACL injury are more likely to develop early onset post-traumatic osteoarthritis despite reconstruction. The purpose of our study was to evaluate the longitudinal changes in the tibiofemoral cartilage contact area size and location after ACL injury and reconstruction. Thirty-one patients with isolated unilateral ACL injury were followed with T weighted Fast Spin Echo, T and T MRI at baseline prior to reconstruction, and 6 months, 1 year, and 2 years after surgery. Areas were delineated in FSE images with an in-house Matlab program using a spline-based semi-automated segmentation algorithm. Tibiofemoral contact area and centroid position along the anterior-posterior axis were calculated along with T and T relaxation times on both the injured and non-injured knees. At baseline, the injured knees had significantly smaller and more posteriorly positioned contact areas on the medial tibial surface compared to corresponding healthy knees. These differences persisted 6 months after reconstruction. Moreover, subjects with more anterior medial centroid positions at 6 months had elevated T and T measures in the posterior medial tibial plateau at 1 year. Changes in contact area and centroid position after ACL injury and reconstruction may characterize some of the mechanical factors contributing to post-traumatic osteoarthritis. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2718-2727, 2018.

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“…Biomechanically, the ankle, with its high congruency, acts as a rolling joint with high congruency (22). The knee, however, acts as a rolling, sliding, and rotating joint during motion (24). This is the principal difference for increased cartilage degeneration and the high rate of primary OA in the knee.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, among individuals aged between 21 and 39 years, there are 10 who scored AOFAS = <19. More than double(24) are present in the age class[40, 59]. Furthermore we found that the number of normal weight patients is always superior to obese class I patients except in patients 40-59 y.o.…”

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confidence: 85%

Post-traumatic ankle osteoarthritis: quality of life, frequency and associated factors

D’Ambrosi

Silvestri

Manzi

et al. 2019

Muscle Ligaments and Tendons J

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Background. To assess the quality of life in patients with post-traumatic ankle osteoarthritis (PTOA) and evaluate frequency and relationship between dependent and independent factors. Methods. We performed a prospective study of patients with post-traumatic ankle osteoarthritis analyzing American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, VAS, Short-Form Health Survey (SF-12) divided into mental (MCS) and physical (PCS) component. Results. Our sample consisted of 258 patients, 162 (62.79%) males and 96 (37.21%) females, with a mean age of 53.6±13.58. In 141 (54.65%) cases the right ankle was affected, in 117 (45.35%) the left. Overweight patients (BMI 25.0-29.99) was the predominant class (43%). PCS and MCS resulted respectively 33.15 and 41.53. We found a positive correlation between PCS and AOFAS (p-value=0.02644 R=0.14) and a negative correlation between AOFAS and VAS (p-value<0.0001, R=-0.30), VAS and PCS (p-value=0.0109, R=-0.16) and MCS and PCS (p-value=0.02696, R=-0.14). Conclusions. PTOA impact patient's quality of life in an important way with limitations in daily activities. Around the age of 35, the physical and mental values of SF-12 tend to be very different. Almost half of the patients were overweight, while we did not find any differences as regards the affected side.

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Functional knee assessment with advanced imaging

Cited by 11 publications

References 60 publications

Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Longitudinal analysis of tibiofemoral cartilage contact area and position in ACL reconstructed patients

Post-traumatic ankle osteoarthritis: quality of life, frequency and associated factors

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