Functional evaluation of alzheimer patients during clinical trials: A review

Bavazzano, A.; Magnolfi, Stefano; Calvani, D.; Valente, C.; Boni, Fabrizio; Baldini, Andrea; Quesada, James

doi:10.1016/s0167-4943(98)80005-8

Cited by 18 publications

(13 citation statements)

References 32 publications

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“…Assessing changes in functional ability over time is essential for intervention studies because functional measures are directly related to caregiver burden [38] and are of specific relevance to the quality of life of the patient [39]. Additionally, they show less learning effects compared with cognitive ones [38] and results are less influenced by education, gender, and age [40].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, they show less learning effects compared with cognitive ones [38] and results are less influenced by education, gender, and age [40]. Therefore, the A-IADL-Q can be of great relevance as an outcome measure in future randomized clinical trials using various approaches and may be of more use than other IADL instruments where the responsiveness has not been supported [3].…”

Section: Discussionmentioning

confidence: 99%

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The sensitivity to change over time of the Amsterdam IADL Questionnaire^©

Koster

Knol

Uitdehaag

et al. 2015

Alzheimer's & Dementia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The sensitivity to change over time of the Amsterdam IADL Questionnaire^©

Koster

Knol

Uitdehaag

et al. 2015

Alzheimer's & Dementia

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“…Previous reviews described only the content of the scales or a limited number of psychometric properties, without evaluating those using clear criteria 8 53 – 56…”

Section: Discussionmentioning

confidence: 99%

A systematic review of Instrumental Activities of Daily Living scales in dementia: room for improvement

Sikkes

Klerk

Pijnenburg

et al. 2008

Journal of Neurology, Neurosurgery & Psychiatry

230

175

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Background: Instrumental Activities of Daily Living (IADL) questionnaires can be helpful in diagnosing dementia and are often used for clinical follow-up and treatment evaluation in dementia patients. Despite the large number of questionnaires, their quality has received little attention. Objective: To systematically review the measurement properties of all available structured informant-based (I)ADL questionnaires, developed or validated for use in demented patients. Methods: A systematic literature search was conducted in MEDLINE, PsycINFO and EMBASE for psychometric articles on (I)ADL questionnaires. In addition, reference lists of all retrieved articles were screened. Standardised criteria were used to assess the quality of the measurement properties. When possible, investigators were contacted to obtain missing information. Two authors independently extracted studies and performed the quality assessment of the questionnaires. Findings: Thirty-two articles were selected, covering 12 (I)ADL questionnaires. Information on 52.3% of the quality aspects was not available, 32.4% of the ratings were indeterminate, 8.1% were positive, and 7.2% were negative. Out of eight measurement properties, two scales (the DAD and the Bristol ADL) received two positive ratings and were classified as of moderate quality. Five scales (ADL-PI, ADL-IS, B-ADL, CSADL and Lawton IADL) received one positive rating. Interpretation: The findings indicate that improvements in and more data on psychometric properties of (I)ADL questionnaires for dementia patients are necessary in order to justify their use.Functional decline is an essential feature of all dementias and is therefore embedded in the diagnostic criteria for dementia.

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“…This interference in everyday functioning is generally measured using informant-based questionnaires aimed at instrumental activities of daily living (IADL) [2]. However, the psychometric quality of these questionnaires has been questioned in several reviews and improvements in IADL questionnaires were recommended [3,4,5]. …”

Section: Introductionmentioning

confidence: 99%

Validation of the Amsterdam IADL Questionnaire©, a New Tool to Measure Instrumental Activities of Daily Living in Dementia

et al. 2013

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Background: This study describes the validation of a new instrument measuring instrumental activities of daily living (IADL), the Amsterdam IADL Questionnaire© (a registered copyright of the Alzheimer Center of the VU University Medical Center). This informant-based tool aimed at detecting IADL problems in incipient dementia was previously found to have a high internal consistency and test-retest reliability. Methods: Patients and their informants who visited the Alzheimer Center of the VU University Medical Center were included in this study. Item response theory was used to estimate the individuals' trait levels as a measure of IADL disability. Construct validity was tested by correlating estimated trait levels with clinical and demographic measures using Pearson's or Kendall's τ correlation coefficients. Additionally, estimated trait levels between patients with and without dementia and between patients with early- and late-onset dementia were compared using independent t tests. Results: A total of 206 informants of patients completed the Amsterdam IADL Questionnaire. The correlations between estimated trait levels and other measures were in concordance with previously formed hypotheses. Patients diagnosed with dementia (n = 93) had higher estimated trait levels than patients without dementia (n = 96), Cohen's effect size, d = 1.04, t(187) = 7.1, p < 0.001. We found no differences between early- and late-onset dementia patients. Conclusions: Results suggest that the Amsterdam IADL Questionnaire is a reliable and valid instrument in the evaluation of dementia.

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Functional evaluation of alzheimer patients during clinical trials: A review

Cited by 18 publications

References 32 publications

The sensitivity to change over time of the Amsterdam IADL Questionnaire^©

The sensitivity to change over time of the Amsterdam IADL Questionnaire^©

A systematic review of Instrumental Activities of Daily Living scales in dementia: room for improvement

Validation of the Amsterdam IADL Questionnaire©, a New Tool to Measure Instrumental Activities of Daily Living in Dementia

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Functional evaluation of alzheimer patients during clinical trials: A review

Cited by 18 publications

References 32 publications

The sensitivity to change over time of the Amsterdam IADL Questionnaire©

The sensitivity to change over time of the Amsterdam IADL Questionnaire©

A systematic review of Instrumental Activities of Daily Living scales in dementia: room for improvement

Validation of the Amsterdam IADL Questionnaire©, a New Tool to Measure Instrumental Activities of Daily Living in Dementia

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Product

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The sensitivity to change over time of the Amsterdam IADL Questionnaire^©

The sensitivity to change over time of the Amsterdam IADL Questionnaire^©