L K Venkatesh, C Yang, P A Theodorakis, G Chinnadurai
Abstract:The bell gene of human spumaretrovirus (HSRV) codes for a 300-amino-acid nuclear protein, termed Bell, that can strongly activate transcription from the cognate long terminal repeat (LTR) by at least 200-fold. Bell can also activate human immunodeficiency virus type 1 (H1V-i) LTR expression. By using site-directed mutagenesis, we have identified distinct regions of Bell essential for HSRV LTR activation. The aminoterminal 55 residues, which comprise a highly acidic region followed by a short basic stretch, wer…
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