Functional Decline in Parkinson Disease

Abstract

Based on longitudinal follow-up data, our findings provide evidence for a variable course of progression of the different PD symptoms, thus implying different biochemical or degenerative mechanisms for the various clinical features associated with PD.

Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory Dance Learning over 3-Years: A Preliminary Longitudinal Investigation

“…This study is the first to show that neither the motor nor the non-motor PD symptoms progress in this disease with participation in longitudinal neurorehabilitation training over three years (of our 10-year on-going project). This is markedly different from all previous studies, which showed annual rates of decline for PD increasing at a slope rate of 0.704%/year [ 28 ] or 5.2–8.9/year within the first 5 years [ 29 ]. Additionally, we confirmed this continual decline in a new cohort—our matched PD non-dance group (PD-Reference), where for the duration of the study these subjects had zero hours of exercise involving dance as measured by questions 4b and 5b of the PASE.…”

Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory Dance Learning over 3-Years: A Preliminary Longitudinal Investigation

“…This study is the first to show that neither the motor nor the non-motor PD symptoms progress in this disease with participation in longitudinal neurorehabilitation training over three years (of our 10-year on-going project). This is markedly different from all previous studies, which showed annual rates of decline for PD increasing at a slope rate of 0.704%/year [ 28 ] or 5.2–8.9/year within the first 5 years [ 29 ]. Additionally, we confirmed this continual decline in a new cohort—our matched PD non-dance group (PD-Reference), where for the duration of the study these subjects had zero hours of exercise involving dance as measured by questions 4b and 5b of the PASE.…”

Progression in the LRRK2-Associated Parkinson Disease Population

“…Our rate of change in the UPDRS for patients with IPD is within the range of that seen in other studies, which reported a progression on the UPDRS III motor score ranging from approximately 0.7 to 2.7 points per year. [23][24][25] Our overall motor finding also contrasts with that in a smaller prospective longitudinal study focused on the change in UPDRS score. 6 In a Tunisian cohort of patients with PD, patients with PD who carry the LRRK2 G2019S mutation were compared with patients with Longitudinal trajectories of mean UPDRS III scores show slower progression for patients with PD who carry the LRRK2 mutation than for patients with IPD.…”

Statistical Models of Parkinson’s Disease Progression: Predictive Validity in a 3-Year Follow-up

“…No significant associations were found between sex and test scores. Our study did not confirm reports in the literature that suggest that male patients may have greater progression of symptoms [58, 64] or different progression of motor scores during different phases of the disease [35].…”

Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory Dance Learning over 3-Years: A Preliminary Longitudinal Investigation

“…This study is the first to show that neither the motor nor the non-motor PD symptoms progress in this disease with participation in longitudinal neurorehabilitation training over three years (of our 10-year on-going project). This is markedly different from all previous studies, which showed annual rates of decline for PD increasing at a slope rate of 0.704%/year [ 28 ] or 5.2–8.9/year within the first 5 years [ 29 ]. Additionally, we confirmed this continual decline in a new cohort—our matched PD non-dance group (PD-Reference), where for the duration of the study these subjects had zero hours of exercise involving dance as measured by questions 4b and 5b of the PASE.…”

Progression in the LRRK2-Associated Parkinson Disease Population

“…Our rate of change in the UPDRS for patients with IPD is within the range of that seen in other studies, which reported a progression on the UPDRS III motor score ranging from approximately 0.7 to 2.7 points per year. [23][24][25] Our overall motor finding also contrasts with that in a smaller prospective longitudinal study focused on the change in UPDRS score. 6 In a Tunisian cohort of patients with PD, patients with PD who carry the LRRK2 G2019S mutation were compared with patients with Longitudinal trajectories of mean UPDRS III scores show slower progression for patients with PD who carry the LRRK2 mutation than for patients with IPD.…”

Statistical Models of Parkinson’s Disease Progression: Predictive Validity in a 3-Year Follow-up

“…No significant associations were found between sex and test scores. Our study did not confirm reports in the literature that suggest that male patients may have greater progression of symptoms [58, 64] or different progression of motor scores during different phases of the disease [35].…”

Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory Dance Learning over 3-Years: A Preliminary Longitudinal Investigation

“…This study is the first to show that neither the motor nor the non-motor PD symptoms progress in this disease with participation in longitudinal neurorehabilitation training over three years (of our 10-year on-going project). This is markedly different from all previous studies, which showed annual rates of decline for PD increasing at a slope rate of 0.704%/year [ 28 ] or 5.2–8.9/year within the first 5 years [ 29 ]. Additionally, we confirmed this continual decline in a new cohort—our matched PD non-dance group (PD-Reference), where for the duration of the study these subjects had zero hours of exercise involving dance as measured by questions 4b and 5b of the PASE.…”

Progression in the LRRK2-Associated Parkinson Disease Population

“…Our rate of change in the UPDRS for patients with IPD is within the range of that seen in other studies, which reported a progression on the UPDRS III motor score ranging from approximately 0.7 to 2.7 points per year. [23][24][25] Our overall motor finding also contrasts with that in a smaller prospective longitudinal study focused on the change in UPDRS score. 6 In a Tunisian cohort of patients with PD, patients with PD who carry the LRRK2 G2019S mutation were compared with patients with Longitudinal trajectories of mean UPDRS III scores show slower progression for patients with PD who carry the LRRK2 mutation than for patients with IPD.…”

Statistical Models of Parkinson’s Disease Progression: Predictive Validity in a 3-Year Follow-up

“…No significant associations were found between sex and test scores. Our study did not confirm reports in the literature that suggest that male patients may have greater progression of symptoms [58, 64] or different progression of motor scores during different phases of the disease [35].…”