2021
DOI: 10.1186/s12979-021-00232-1
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Abstract: At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune system promotes survival upon pathogenic infection. Substantial evidence however points to a molecularly intertwined relationship between the immune system and ageing. Although this link is well-known throughout the animal kingdom, its genetic basis is complex and still poorly understood. To address this question, we here provide a compilation of all genes concomitantly known to be… Show more

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Cited by 38 publications
(15 citation statements)
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References 220 publications
(249 reference statements)
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“…In D. melanogaster TEs affect the expression of immunity genes (14), and we have reported a Doc element insertion that is associated with resistance to the virus DMelSV (15,16). In insects and other invertebrates, the absence of an adaptive immune system means infection must be controlled by innate immune defences (17), with the RNAi pathway being a key defence against viruses (18). While these core immune pathways evolve rapidly (19,20), it is unclear what role they play in the evolution of resistance.…”
Section: Introductionmentioning
confidence: 99%
“…In D. melanogaster TEs affect the expression of immunity genes (14), and we have reported a Doc element insertion that is associated with resistance to the virus DMelSV (15,16). In insects and other invertebrates, the absence of an adaptive immune system means infection must be controlled by innate immune defences (17), with the RNAi pathway being a key defence against viruses (18). While these core immune pathways evolve rapidly (19,20), it is unclear what role they play in the evolution of resistance.…”
Section: Introductionmentioning
confidence: 99%
“…Despite discrepancies between bear and mouse models (e.g., fed status, torpor vs. hindlimb muscle disuse), both display similar pathways controlling skeletal muscle mass and protein balance. For instance, the TGF-β signaling pathway has been reported to be evolutionarily conserved among several species, from Caenorhabditis elegans and Drosophila melanogaster to Mus musculus [68]. In addition, both models are responsive to denervation-induced atrophy when in active conditions [20,30].…”
Section: Discussionmentioning
confidence: 99%
“…We anticipate that such insights focused on understanding RAS biology in cancer and RASopathies will have broad implications for many classes of diseases. Along such lines, targeting of the RAS pathway in diseases of aging ( Fabian et al, 2021 ; Slack et al, 2015 ) and neurological disorders ( Park et al, 2013 ; Qu et al, 2019 ) with anti-cancer therapeutics has already demonstrated promise for advances in these areas.…”
Section: Voices Beyond This Special Issuementioning
confidence: 99%