volume 13, issue 5, Pe0197487 2018
DOI: 10.1371/journal.pone.0197487
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Elisa Meroni, Nathalie Stakenborg, Pedro J. Gomez-Pinilla, Gert De Hertogh, Gera Goverse, Gianluca Matteoli, Simon Verheijden, Guy E. Boeckxstaens

Abstract: BackgroundOxazolone-induced colitis has been frequently used in literature as a model of IBD, but insights into the underlying immune response and pathological features are surprisingly still very limited. Vagus nerve stimulation (VNS) has proven to be effective in innate and Th1/Th17 predominant inflammatory models, including pre-clinical models of colitis, however to what extent VNS is also effective in ameliorating Th2-driven colitis remains to be studied. In the present study, we therefore further characte…

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