Abstract:In the last years, the Hippo signaling has emerged as an essential pathway to control tissue and organ homeostasis, and its deregulation leads to tumoral transformation in all animals studied. However, the underlying cellular and molecular mechanism of this transformation are still not clear. The core of the Hippo pathway includes a kinase cassette composed by the kinases Hippo, Salvador, Mats, and Warts that in turn phosphorylates the nuclear effector of the pathway, Yorkie, targeting it to proteasomal degrad… Show more
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