Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs

Ali, Aliaa A.; Bhadane, Rajendra; Asl, Afshin Ansari; Wilén, Carl‐Eric; Salo‐Ahen, Outi M. H.; Rosenholm, Jessica M.; Bansal, Kuldeep K.

doi:10.1039/d2ra03962a

Cited by 7 publications

(6 citation statements)

References 68 publications

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“…In fact, several factors may influence ζ potential, including ionic strength, the concentration of any additives, pH, and temperature 55 . Apparently, the Dtx and/or Res encapsulated into micelles had an impact on the change of the ζ potential, which was reported also for other drugs 56 . The size of blank PLLA‐PEG and PDLLA‐PEG micelles was similar (≈100 nm), however, significant differences were observed after drug loading (Table 3).…”

Section: Discussionmentioning

confidence: 69%

“…55 Apparently, the Dtx and/or Res encapsulated into micelles had an impact on the change of the ζ potential, which was reported also for other drugs. 56 The size of blank PLLA-PEG and PDLLA-PEG micelles was similar (≈100 nm), however, significant differences were observed after drug loading (Table 3). Also, the differences between PLLA-PEG and PDLLA-PEG were observed in drug loading and release properties (Table 4, Figure 3).…”

Section: Discussionmentioning

confidence: 88%

“…Drug release from polymeric micelles can occur due to either drug diffusion from intact micelles, micelles disassembly, and degradation of polymer-forming micelles. 50,56 However, the inter-and intramolecular interaction of drug-drug, and drug-polymer type are also able to influence the drug release rate and profile. 57 As presented in the FT-IR spectrum of PLLA-PEG/Dtx and PLLA-PEG/Dtx + Res (Figure 4), some changes were observed for the C=O urethane groups of Dtx, which indicates modification of the distribution of the C=O---H-N hydrogen bonds caused by interactions between PLLA-PEG and Dtx.…”

Section: Discussionmentioning

confidence: 99%

“…Contrary to Dtx, rapid release of Res was observed from single‐ and dual‐drug micelles, regardless of the polymer. Drug release from polymeric micelles can occur due to either drug diffusion from intact micelles, micelles disassembly, and degradation of polymer‐forming micelles 50,56 . However, the inter‐ and intramolecular interaction of drug–drug, and drug–polymer type are also able to influence the drug release rate and profile 57 .…”

Section: Discussionmentioning

confidence: 99%

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Comparison of PLLA‐PEG and PDLLA‐PEG micelles for co‐encapsulation of docetaxel and resveratrol

Jurczyk,

Musiał‐Kulik,

Foryś

et al. 2023

J Biomed Mater Res

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The interest in combining chemosensitizers with cytostatics in cancer therapy is growing, which causes also a need to develop their delivery systems. Example of the combination with beneficial therapeutic effects is docetaxel (Dtx) and resveratrol (Res). Although poly(lactide)‐co‐poly(ethylene glycol) (PLA–PEG) micelles have been considered as one of the most promising platforms for drug delivery, their properties may depend on the stereoisomeric form of hydrophobic block. Therefore, the aim of this study was evaluation of the effect of PLA block on co‐encapsulation and release rate of Dtx and Res, which has not been studied so far. This article presents a comparison of single‐ (Dtx or Res) and dual‐drug (Dtx and Res) loaded micelles obtained from poly(l,l‐lactide)‐co‐poly(ethylene glycol) (PLLA‐PEG) and poly(d,l‐lactide)‐co‐poly(ethylene glycol) (PDLLA‐PEG). The analyzes of the micelles have been conducted including morphology, drug(s) encapsulation efficiency, intermolecular interactions, in vitro drug release, and cytotoxicity. Differences in drug loading ability and release profile have been observed between Res and Dtx but also depending on the polymer and number of drugs in micelles (single vs. dual loaded). The PLLA‐PEG micelles have a significantly higher Dtx encapsulation capacity than PDLLA‐PEG micelles. The highest cytotoxicity was shown for Dtx and Res dual‐loaded micelles, regardless of the polymer. The findings may be used for selection of PLA‐based drug delivery systems containing Dtx and Res.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of PLLA‐PEG and PDLLA‐PEG micelles for co‐encapsulation of docetaxel and resveratrol

Jurczyk,

Musiał‐Kulik,

Foryś

et al. 2023

J Biomed Mater Res

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“…334-fold compared to Soluplus ® . Hence, it was proposed that the solubilization capability of polymeric micelles can be enhanced drastically via the introduction of a free functional group on the polymer chain, which can interact with drugs electrostatically [ 114 , 115 ]. Zhou et al synthesized griseofulvin-loaded core crosslinked micelles to increase solubility and stability.…”

Section: Nanotechnological Approaches For Solubility Enhancementmentioning

confidence: 99%

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Kumari

Choudhari

Patel

et al. 2023

Life

Self Cite

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A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are poorly soluble, which results in low bioavailability, diminished therapeutic effects, and dosage escalation. Because of this, solubility must be taken into consideration when developing and fabricating pharmaceutical products. To date, a number of approaches have been investigated to address the problem of poor solubility. This review article attempts to summarize several conventional methods utilized to increase the solubility of poorly soluble drugs. These methods include the principles of physical and chemical approaches such as particle size reduction, solid dispersion, supercritical fluid technology, cryogenic technology, inclusion complex formation techniques, and floating granules. It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use of co-solvents, hydrotrophy, polymorphs, amorphous solid dispersions, and pH variation). Various nanotechnological approaches such as liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, and so forth have also been widely investigated for solubility enhancement. All these approaches have brought forward the enhancement of the bioavailability of orally administered drugs by improving the solubility of poorly water-soluble drugs. However, the solubility issues have not been completely resolved, owing to several challenges associated with current approaches, such as reproducibility in large scale production. Considering that there is no universal approach for solving solubility issues, more research is needed to simplify the existing technologies, which could increase the number of commercially available products employing these techniques.

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Recent advances in long-acting drug delivery systems for anticancer drug

Pacheco

Baião

Ding

et al. 2023

Advanced Drug Delivery Reviews

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Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs

Abstract: Block copolymer micelles with a functional core have been synthesized and evaluated for their drug delivery capability. High drug loading was observed due to strong ionic interactions, while cytotoxicity of polymers was found to be low.

Cited by 7 publications

References 68 publications

Comparison of PLLA‐PEG and PDLLA‐PEG micelles for co‐encapsulation of docetaxel and resveratrol

Comparison of PLLA‐PEG and PDLLA‐PEG micelles for co‐encapsulation of docetaxel and resveratrol

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Recent advances in long-acting drug delivery systems for anticancer drug

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