Functional Asymmetry for Auditory Processing in Human Primary Auditory Cortex

Devlin, Joseph T.; Raley, Josephine M.; Tunbridge, Elizabeth; Lanary, Katherine; Floyer-Lea, Anna; Narain, Charvy; Cohen, Ian S.; Behrens, Timothy E.J.; Jezzard, Peter; Matthews, Paul M.; Moore, David R.

doi:10.1523/jneurosci.23-37-11516.2003

Cited by 111 publications

(74 citation statements)

References 59 publications

(76 reference statements)

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“…A leftward lateralization of the A1 in healthy subjects has been described previously, both for linguistic and nonlinguistic stimuli [42,43]. This is thought to be due to the A1's involvement in language processing, which is also left-lateralized in the majority of people, by screening incoming sounds for speech [44].…”

Section: Discussionmentioning

confidence: 77%

Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus

et al. 2007

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Introduction Tinnitus is hypothesized to be an auditory phantom phenomenon resulting from spontaneous neuronal activity somewhere along the auditory pathway. We performed fMRI of the entire auditory pathway, including the inferior colliculus (IC), the medial geniculate body (MGB) and the auditory cortex (AC), in 42 patients with tinnitus and 10 healthy volunteers to assess lateralization of fMRI activation. Methods Subjects were scanned on a 3T MRI scanner. A T2*-weighted EPI silent gap sequence was used during the stimulation paradigm, which consisted of a blocked design of 12 epochs in which music presented binaurally through headphones, which was switched on and off for periods of 50 s. Using SPM2 software, single subject and group statistical parametric maps were calculated. Lateralization of activation was assessed qualitatively and quantitatively. Results Tinnitus was lateralized in 35 patients (83%, 13 right-sided and 22 left-sided). Significant signal change (P corrected <0.05) was found bilaterally in the primary and secondary AC, the IC and the MGB. Signal change was symmetrical in patients with bilateral tinnitus. In patients with lateralized tinnitus, fMRI activation was lateralized towards the side of perceived tinnitus in the primary AC and IC in patients with right-sided tinnitus, and in the MGB in patients with left-sided tinnitus. In healthy volunteers, activation in the primary AC was left-lateralized. Conclusion Our paradigm adequately visualized the auditory pathways in tinnitus patients. In lateralized tinnitus fMRI activation was also lateralized, supporting the hypothesis that tinnitus is an auditory phantom phenomenon.

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Section: Discussionmentioning

confidence: 77%

Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus

et al. 2007

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“…Human opercular temporal cortex or planum temporale is demonstrated to be anatomically and functionally lateralized on the left hemisphere (Geschwind and Levitsky, 1968;Devlin et al, 2003). Because the region contains primary and associative auditory cortex and the posterior part constitutes Wernicke's area, these asymmetries are often cited as the anatomical basis of the left hemisphere dominance for language.…”

Section: Discussionmentioning

confidence: 99%

Multiple Bases of Human Intelligence Revealed by Cortical Thickness and Neural Activation

Choi¹,

Shamosh²,

Cho³

et al. 2008

J. Neurosci.

196

162

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We hypothesized that individual differences in intelligence (Spearman's g) are supported by multiple brain regions, and in particular that fluid ( gF) and crystallized ( gC) components of intelligence are related to brain function and structure with a distinct profile of association across brain regions. In 225 healthy young adults scanned with structural and functional magnetic resonance imaging sequences, regions of interest (ROIs) were defined on the basis of a correlation between g and either brain structure or brain function. In these ROIs, gC was more strongly related to structure (cortical thickness) than function, whereas gF was more strongly related to function (blood oxygenation level-dependent signal during reasoning) than structure. We further validated this finding by generating a neurometric prediction model of intelligence quotient (IQ) that explained 50% of variance in IQ in an independent sample. The data compel a nuanced view of the neurobiology of intelligence, providing the most persuasive evidence to date for theories emphasizing multiple distributed brain regions differing in function.

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“…Contralateral dominance for cortical auditory processing was shown with fMRI using noise bursts or tones presented to one ear, but these studies did not allow for differential appreciations of AI and the non-primary cortex (Jancke et al, 2002;Schonwiesner et al, 2007;Woldorff et al, 1999;Woods et al, 2009). Using 3-T fMRI, Devlin et al (2003) investigated activation (Scott and Johnsrude, 2003) and of AA and ALA in the recognition of environmental sounds (as opposed to sound localisation; Viceic et al, 2006). The activation by environmental sounds is strongly modulated by the spatial position of the sound in areas PA, LA and STA, weakly in AI and ALA and not at all in AA and MA (Fig.…”

Section: Auditory Responses Modulated By Positional Informationmentioning

confidence: 99%