Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of <i>Pseudocerastes persicus</i>

Amininasab, Mehriar; Elmi, Maryam; Endlich, Nicole; Endlich, Karlhans; N, Parekh; Naderi-Manesh, Hossein; Schaller, Johann; Mostafavi, Hossein; Sattler, Michael; Sarbolouki, M. N.; Muhle‐Goll, Claudia

doi:10.1016/s0014-5793(03)01455-8

Cited by 31 publications

(17 citation statements)

References 30 publications

(29 reference statements)

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“…Notably, antiplatelet activities have also been reported in a 37-residue peptide, Pseudocerastes persicus natriuretic peptide (PNP), which was isolated from the venom of the Iranian viper, Pseudocerastes persicus [103]. In addition, Michel et al [104] reported the isolation of two N-terminally truncated forms of CNP from the venom of Trimeresurus flavoviridis (habu snake): Tf-CNP (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) and Tf-CNP (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) [104].…”

Section: Dendroaspis Natriuretic Peptide and Other Snake Venomsmentioning

confidence: 99%

Natriuretic peptides and therapeutic applications

2007

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Since the discovery of atrial natriuretic factor by de Bold et al., there has been tremendous progress in our understanding of the physiologic, diagnostic and therapeutic roles of the natriuretic peptides (NPs) in health and disease. Natriuretic peptides are endogenous hormones that are released by the heart in response to myocardial stretch and overload. Three mammalian NPs have been identified and characterized, including atrial natriuretic peptide (ANP or atrial natriuretic factor), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). In addition, Dendroaspis natriuretic peptide (DNP) has been isolated from the venom of Dendroaspis angusticeps (the green mamba snake), and urodilatin from human urine. These peptides are structurally similar and they consist of a 17-amino-acid core ring and a cysteine bridge. Both ANP and BNP bind to natriuretic peptide receptor A (NPR-A) that are expressed in the heart and other organs. Activation of NPR-A generates an increase in cyclic guanosine monophosphate, which mediates natriuresis, inhibition of renin and aldosterone, as well as vasorelaxant, anti-fibrotic, anti-hypertrophic, and lusitropic effects. The NP system thus serves as an important compensatory mechanism against neurohumoral activation in heart failure. This provides a strong rationale for the use of exogenous NPs in the management of acutely decompensated heart failure. In this article, the therapeutic applications of NPs in the acute heart failure syndromes are reviewed. Emerging therapeutic agents and areas for future research are discussed.

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Section: Dendroaspis Natriuretic Peptide and Other Snake Venomsmentioning

confidence: 99%

Natriuretic peptides and therapeutic applications

2007

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“…By contrast, in flexible peptides 1 H a chemical shifts depend mostly on the nature of the attached sidechain, with the identity of neighbouring residues in the sequence having only small effects. After changes in solution conditions and amino acid composition are taken into account, the 1 H N and 1 H a chemical shifts of ANP ox differ little from those recorded in earlier studies of a hexamutant ANP variant (Fairbrother et al, 1994) and of more obviously random coil homologues including urodilatin, which has a 4 amino acid extension at the N-terminus (Weber et al, 1994), and PNP, a natriuretic peptide found in the venom of the snake Pseudocerastes persicus (Amininasab et al, 2004).…”

Section: Resonance Assignmentsmentioning

confidence: 63%

Backbone dynamics of oxidised and reduced forms of human atrial natriuretic peptide

Peto

Stott

Sunde

et al. 2004

Journal of Structural Biology

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“…40 The rst reptilian NP was isolated from the venom of the Eastern green mamba (Dendroaspis angusticeps), and was termed Dendroaspis natriuretic peptide (DNP). 44 Subsequently, reptilian NPs were puried from the venoms of Pseudocerastes persicus, 45 Oxyuranus microlepidotus, 46 Crotalus durissus cascavella (¼C. d. terricus), 47 Micrurus corallinus, 48 Bungarus avi-ceps, 49 and Agkistrodon halys blomhoffii (¼Gloydius blomhoffii blomhoffii).…”

Section: Natriuretic Peptidesmentioning

confidence: 99%