Functional and Morphologic Evaluation of Congenital Urinary Tract Dilatation by Using Combined Static-Dynamic MR Urography: Findings in Kidneys with a Single Collecting System

Rohrschneider, W; Haufe, Sabine; Wiesel, M.; Tönshoff, Burkhard; Wünsch, R.; Darge, Kassa; Clorius, John H.; Tröger, J.

doi:10.1148/radiol.2243011207

Cited by 133 publications

(75 citation statements)

References 45 publications

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“…MRU is effective in investigation of pediatric uropathological conditions and in the investigating of the congenital anomalies. It provides morphological and functional information (9).…”

Section: Radioisotope Investigationsmentioning

confidence: 99%

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

Ristoska-Bojkovska¹

2017

Prilozi

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Congenital anomalies of the kidneys and urinary tract (CAKUT) are found in 3-6 out of 1.000 of the newborns, or according to some statistics they are represented in 0.5% of all pregnancies. Congenital abnormalities of the kidneys and urinary tract present a family of diseases of various anatomic spectrum, including renal anomalies, and anomalies of the bladder and urethra. The study was retrospective-prospective which means that it included newly diagnosed patients suffering from CAKUT, as well as those patients with already diagnosed and well defined CAKUT on the basis of imaging studies which have been processed according to the protocol for this study.

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“…MRU is effective in investigation of pediatric uropathological conditions and in the investigating of the congenital anomalies. It provides morphological and functional information (9).…”

Section: Radioisotope Investigationsmentioning

confidence: 99%

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

Ristoska-Bojkovska¹

2017

Prilozi

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“…The results achieved in the studies performed to evaluate MR urography and renal function numerically in literature are towards the possibility that it can be the alternative of the diuretic renal scintigraphy (Borthne et al, 2000;Avni et al, 2002;Rohrschneider et al, 2002;Zielonko et al, 2003). A dynamic MR urography technique that enables the calculation of single kidney function similarly with the scintigraphy was used in our study.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance urography in the assesment of congenital urinary system dilatation in pediatric patients

Kılınç¹,

Subaşi²,

Kaya³

2013

jecm

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Article HistoryReceived 04 / 05 / 2013 Accepted 21 / 05 / 2013The aim of this study is to assess combined static-dynamic magnetic resonance (MR) urography in the evaluation of urinary tract anomalies in infants and children. Thirthynine patients with urinary tract anomalies underwent retrospective examination between 2009-2012, with combined static-dynamic MR urography. A combination examination involved use of a static T2-weighted thick slap spin-echo sequence and a dynamic T1-weighted tree-dimensional spoiled gradient-echo-recalled sequence with gadopentetate dimeglumine-DTPA and furosemide application. Morphologic results were compared with those of ultrasonography and, when available, surgery. The dynamic sequence was used to calculate renal transit time (RTT), split renal function from renograms generated from parenchymal regions of interest and to assess urinary excretion from whole-kidney renograms. Results were compared with those of diuretic renal scintigraphy for split function and urinary excretion. Urinary system dilatations caused by stenosis at the ureteropelvic (n=16), ureterovesical (n=4) junctions and within the ureter (n=6), posterior urethral valve (n=1), postoperative urethral obstruction (n=1), neurogenic bladder (n=1) and nonstenotic dilatation (n=4) and urinary tract anomalies, double collecting system (n=4) and isolated urinary tract anomalies (n=2) were clearly depicted. For morphologic evaluation, sensivity of MR urography compared with surgery calculated 82.75% and for split renal function, sensivity of dynamic MR urography compared with diuretic renal scintigraphy (DRS) calculated 80%. For urinary excretion, MR urography and DRS showed strong agreement. MR urografi is a modality with which urinary system pathologies could be both morphologically and functionally evaluated with high accuracy and does not use ionizing radiation. But it has disadvantages for example, children need sedation during examination, results cannot be compared with enough clinical trials because of ethical reasons and some technical incapabilities. But we think with some technical improvements, MR urography can be applied in diagnosis and follow up of urinary system abnormalities in children with high degree of confidency.

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“…Rohrschneider et al [14] studied 62 patients of hydronephrosis using MRI and concluded that image quality was good or excellent in 95% of the cases. For split renal function, dMRI and isotope study showed significant correlation (r=0.92, p<0.001).…”

Section: Discussionmentioning

confidence: 99%

Dynamic MRI and isotope renogram in the functional evaluation of pelviureteric junction obstruction: A comparative study

Sivakumar

Indiran

Sathyanathan

2018

Turkish Journal of Urology

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Cite this article as: : Sivakumar V, Indiran V, Sathyanathan BP. Dynamic MRI and isotope renogram in the functional evaluation of pelviureteric junction obstruction: A comparative study. Turk J Urol 2018; 44(1): 45-50. ORCID IDs of the authors:V.N.S. 0000-0002-5254-8559; V.I. 0000-0001-5296-0175; B.P.S. 0000-0002-4057-0054. ABSTRACTObjective: The aim of this study was to evaluate and compare the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging (dMRI) and isotope renogram in the functional evaluation of pelviureteric junction obstruction (PUJO). Material and methods:Forty-two patients included in the study were investigated with isotope renogram and subsequently, subjected to dMRI. Time-activity curves were generated for both isotope renogram and dMRI. Out of the 42 cases, 9 cases were conservatively managed. Thirty-three cases were taken up for surgical intervention.Results: Of 33 patients taken up for surgical intervention, 12 underwent laparoscopic nephrectomy and 21 of them pyeloplasty. The mean glomerular filtration rates (GFRs) as measured by isotope renogram and dMRI were 22.5+4.2 mL/min and 23.8+3.1 mL/min respectively. The calculation of GFR by isotope renogram, showed good correlation with that of dMRI with correlation coefficient of 0.93. The dMRI was able to reveal the functional status of the renal unit accurately. dMRI did not yield false positive results with 20 of 21 patients scheduled for pyeloplasty and 11 of 12 patients scheduled for nephrectomy. Isotope renogram had a false positive result in 3 cases compared with surgical diagnosis. Conclusion:Analysis of renal function using dMRI yielded results comparable to those of renal scintigraphy, with superior spatial and contrast resolution. It was also better in prompting management decisions with respect to the obstructed systems. dMRI can be used as a "one stop imaging examination" that can replace different imaging methods used for morphological, etiological and functional evaluation of PUJO.

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Functional and Morphologic Evaluation of Congenital Urinary Tract Dilatation by Using Combined Static-Dynamic MR Urography: Findings in Kidneys with a Single Collecting System

Abstract: Combined static-dynamic MR urography provides high-quality depiction of the urinary tract in infants and children, while allowing accurate determination of single-kidney function and reliable evaluation of urinary excretion.

Cited by 133 publications

References 45 publications

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

Magnetic resonance urography in the assesment of congenital urinary system dilatation in pediatric patients

Dynamic MRI and isotope renogram in the functional evaluation of pelviureteric junction obstruction: A comparative study

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