1981
DOI: 10.1084/jem.154.2.459
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Previous studies (1-9) have suggested that peripheral human T cells can be divided into two mutually exclusive functional subsets by the two monoclonal antibodies, OKT8 and OKT4. The OKT8+ subset does not provide helper activity but contains cells capable of suppressing B cell differentiation . Importantly, the suppression observed with OKT8+ cells requires the presence of radiosensitive OKT4 + cells . Potent helper activity is found in a radiosensitive OKT4' subset . Irradiated OKT4+ cells also induced B cell… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

13
94
1

Year Published

1982
1982
2000
2000

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 247 publications
(108 citation statements)
references
References 14 publications
13
94
1
Order By: Relevance
“…These specificities have been established through a number of studies and are commonly accepted [23]. Recently, it has been shown that a fraction of pokeweed mitogen-activated OKT 4 positive T cells contains both helper and suppressor activity [24], and it seems likely that further research, e.g. with newly developed antibodies, will reveal additional functional subpopulations in the OKT 4 and OKT 8 positive T cell subsets.…”
Section: Discussionmentioning
confidence: 99%
“…These specificities have been established through a number of studies and are commonly accepted [23]. Recently, it has been shown that a fraction of pokeweed mitogen-activated OKT 4 positive T cells contains both helper and suppressor activity [24], and it seems likely that further research, e.g. with newly developed antibodies, will reveal additional functional subpopulations in the OKT 4 and OKT 8 positive T cell subsets.…”
Section: Discussionmentioning
confidence: 99%
“…In humans, the recent production of monoclonal antibodies (7,8) to human T cell subsets has enabled the demonstration that Ig synthesis by B cells is also subject to T cell-mediated regulation (9)(10)(11)(12). However, there have been only limited studies of immunoregulatory circuits in man (13)(14)(15).…”
mentioning
confidence: 99%
“…In cord blood (50), suppression is found in the OKT4', rather than the OKT8' population and Reinherz recently (51) described a patient with a functional helper T cell defect, but normal numbers of OKT4' cells. There is also increasing evidence that OKT4' and OKT8' cells are heterogeneous with respect to both function and cell surface determinants (50)(51)(52)(53)(54). Our data demonstrate that ecto-5'-NT activity defines a subpopulation of T cells that overlaps the subpopulations defined by OKT4 and OKT8 and that the proportions of ecto-5'-NT positive and negative T cells is markedly altered in many patients with CAG and CVI.…”
Section: Resultsmentioning
confidence: 52%