Functional analysis of CYP71AV1 reveals the evolutionary landscape of artemisinin biosynthesis
Fang-Yan Chen,
Qiu-Yan Mu,
Bing-Yi Xu
et al.
Abstract:Artemisinin biosynthesis, unique to Artemisia annua, is suggested to have evolved from the ancestral costunolide biosynthetic pathway commonly found in the Asteraceae family. However, the evolutionary landscape of this process is not fully understood. The first oxidase in artemisinin biosynthesis, CYP71AV1, also known as amorpha-4,11-diene oxidase (AMO), has specialized from ancestral germacrene A oxidases (GAOs). Unlike GAO, which exhibits catalytic promiscuity toward amorpha-4,11-diene, the natural substrate… Show more
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