Functional analyses of the superficial stratum corneum in atopic xerosis

Decreased lactate and potassium levels in natural moisturizing factor from the stratum corneum of mild atopic dermatitis patients are involved with the reduced hydration state

“…In contrast to previous studies, which described the reduced levels of FAAs in AD dry skin [14,15,22,23], we were unable to demonstrate any significantly decreased levels of FAAs in AD skin. Some reports stated that the reduced levels of FAAs depend on the severity of AD [15,23].…”

Corneosurfametry and the compromised atopic stratum corneum

“…Indeed, both an altered barrier function and vulnerability of non-eczematous atopic skin have previously been shown by other investigative methods [1,4,9,11,12]. Such functional aspects may be related to the fact that the stratum corneum of apparently uninvolved skin of atopic individuals is thinner and contains less lipid than normal subjects [5,13,14]. This study also confirmed the expectation that the structure and function of atopic stratum corneum is further altered by surfactants.…”

Three‐dimensional analyses of individual corneocytes with atomic force microscope: morphological changes related to age, location and to the pathologic skin conditions

“…Moreover, it is noteworthy that the morphology of some of the cells collected even from the unaffected areas of AD patients was rather similar to that of the cells of the affected areas. The stratum corneum of the unaffected skin of AD patients are known to show various functional abnormalities such as compromised barrier function and reduced water-holding capacity together with increased turnover rate when compared to that of normal skin (18). In contrast, we found that this was not the case with psoriatic patients, in which even clinically the lesional skin looks distinct from the unaffected skin.…”