Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission

Tran, Léa Chantal; Bridoux-Henno, Laure; Gastineau, Swellen; Dabadie, A.; Carré, E.; Hugot, Jean‐Pierre; Martinez-Vinson, Christine; Mosca, Alexis; Coopman, Stéphanie; Lamireau, T.; Enaud, Raphaël; Clouzeau, H.; Bertrand, Valérie; Pigneur, Bénédicte; Ruemmele, Frank M; Degas, Vanessa; Breton, A; Mas, Emmanuel; Lacotte, Édouard; Chaillou-Legault, Emilie; Caron, Nicolas; Languepin, J.; Willot, S.; Bouazza, Ahlem; Spyckerelle, C.; Dimitrov, Georges; Thomassin, Nicolas; Djeddi, D.; Vanrenterghem, A.; Grandjean, Camille; Viala, Jérôme; Dupont-Lucas, Claire

doi:10.1016/j.dld.2021.05.034

Cited by 3 publications

(9 citation statements)

References 29 publications

(37 reference statements)

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“…A recent US survey, based on the Rome IV diagnostic criteria, found that 17% of children and adolescents in the United States had FAPDs (1). FAPDs can present as isolated disorders or overlap with organic diseases such as inflammatory bowel disease (IBD) (2). Patients with FAPDs report notable reduction in quality of life (3).…”

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confidence: 99%

Clinical Hypnosis for Pediatric Gastrointestinal Disorders

Chogle

Lee

Santucci

et al. 2022

J. pediatr. gastroenterol. nutr.

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Functional abdominal pain disorders (FAPDs) are common in the pediatric population and are associated with a significant reduction in quality of life. Bidirectional communication of the brain-gut axis plays an important role in pain generation and perception in FAPDs. There is a paucity of data on the best approach to treat this group of disorders, with no Food and Drug Administration (FDA)-approved drugs and scarce research to substantiate the use of most medications. Use of hypnosis in pediatric FAPDs is supported by evidence and has long-term benefits of up to at least 5 years beyond completion of treatment, highlighting the importance of incorporating this therapy into the care of these patients. The mechanisms by which clinical hypnosis is beneficial in the treatment of FAPDs is not completely understood, but there is growing evidence that it impacts functioning of the brain-gut axis, potentially through influence on central pain processing, visceral sensitivity, and motility. The lack of side effects or potential for significant harm and low cost makes it an attractive option compared to pharmacologic therapies. This review addresses current barriers to clinical hypnosis including misconceptions among patients and families, lack of trained clinicians, and questions around insurance reimbursement. The recent use of telemedicine and delivery of hypnosis via audio-visual modalities allow more patients to benefit from this treatment. As the evidence base for hypnosis grows, acceptance and training will likely increase as well. Further research is needed to understand how hypnosis works and to develop tools that predict who is most likely to respond to hypnosis. Studies on cost-effectiveness in comparing hypnosis to other therapies for FAPDs will increase evidence for appropriate healthcare utilization. Because hypnosis has applications beyond pain and is child-friendly with minimal to no risk, hypnosis could be an important therapeutic tool in the wider pediatric gastrointestinal population.

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confidence: 99%

Clinical Hypnosis for Pediatric Gastrointestinal Disorders

Chogle

Lee

Santucci

et al. 2022

J. pediatr. gastroenterol. nutr.

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“…The most recent study reporting on the prevalence of FAPDs in children with IBD in remission was published by Tran et al in 2021. 16 A total of 102 patients were recruited based on the study inclusion remission criteria, defined by physician's global assessment and features that include the absence of each of the following: >3 stools/day, blood in stools, nocturnal stools, ongoing steroid therapy, recurrence of disease or optimization of treatment in the last 3 months. Patient-and parent-reported Rome III Diagnostic Questionnaire for the Pediatric Functional Gastrointestinal Disorders (Fr-qPGS) were utilized to diagnose FGIDs, which included FAPDs and other subclassifications of FGIDs.…”

Section: Resultsmentioning

confidence: 99%

“… 13 The other three studies included patients with either CD or UC, as well as patients with IBD‐U in the study by Tran et al . 14 , 15 , 16 Overall, the prevalence of IBS in children with IBD in remission ranged between 3.9 and 16.1%, while the prevalence of FAPDs in children with IBD in remission ranged between 9.6 and 29.5%. The prevalence of functional abdominal pain was found to be 10.3% based on the result by Zimmerman et al .…”

Section: Discussionmentioning

confidence: 99%

“…had the largest cohort size of 174 patients in remission, though all of the patients included had CD 13 . The other three studies included patients with either CD or UC, as well as patients with IBD‐U in the study by Tran et al 14‐16 . Overall, the prevalence of IBS in children with IBD in remission ranged between 3.9 and 16.1%, while the prevalence of FAPDs in children with IBD in remission ranged between 9.6 and 29.5%.…”

Section: Discussionmentioning

confidence: 99%

“…The study published by Zimmerman et al had the largest cohort size of 174 patients in remission, though all of the patients included had CD. 13 The other three studies included patients with either CD or UC, as well as patients with IBD-U in the study by Tran et al [14][15][16] Overall, the prevalence of IBS in children with IBD in remission ranged between 3.9 and 16.1%, while the prevalence of FAPDs in children with IBD in remission ranged between 9.6 and 29.5%. The prevalence of functional abdominal pain was found to be 10.3% based on the result by Zimmerman et al 13 The study conducted by Zimmerman et al utilized less stringent criteria to determine the presence of functional abdominal pain, as opposed to the well-recognized Rome criteria utilized in the other three articles.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of irritable bowel syndrome and functional abdominal pain disorders in children with inflammatory bowel disease in remission

2022

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Despite evidence of an increased prevalence of irritable bowel syndrome (IBS) in adults with inflammatory bowel disease (IBD) compared with the general population, the prevalence of IBS in children with IBD is unclear. In this review, we aimed to identify the reported prevalence of IBS or functional abdominal pain disorders (FAPDs) in children with IBD in remission. A search of three databases (MEDLINE, Embase, and PubMed) was performed to identify studies reporting the prevalence of IBS or FAPDs in pediatric patients with IBD in remission. A total of 60 studies were identified, with four eligible studies remaining following abstract screening. In children with IBD in remission, the overall prevalence of IBS ranged between 3.9 and 16.1%, and the overall prevalence of FAPDs ranged between 9.6 and 29.5%. The prevalence of FAPDs in patients in biomarker‐based remission was generally higher than those in clinical remission (range 16–22.5% vs 9.6–16.7%, respectively). There is a paucity of literature reporting on the prevalence of IBS or FAPDs in children with IBD in remission. Despite the differences in criteria used to define IBD remission in the included articles, there seems to be an increased overall prevalence of IBS or FAPDs in children with IBD.

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The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis

Beveridge,

Noel,

Soltani

et al. 2023

Pain

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Mental health problems are common among parents of children with chronic pain and associated with worse outcomes for the child with chronic pain. However, the effect sizes of these associations between parent mental health and pediatric chronic pain vary widely across studies. The aim of this systematic review and meta-analysis was to generate pooled estimates of the (1) prevalence of mental health problems among parents of children with chronic pain and (2) associations between parent mental health and the (2a) presence of child chronic pain and (2b) functioning of children with chronic pain. Embase, MEDLINE, PsycINFO, Web of Science, and CINAHL were searched up to November 2022. Observational studies that examined symptoms or diagnoses of parent anxiety, depression, or general distress and the presence of child chronic pain and/or related functioning were included. From 32,848 records, 2 coders identified 49 studies to include in random-effects meta-analyses. The results revealed that mental health problems among parents of children with chronic pain were common (anxiety: 28.8% [95% CI 20.3-39.1]; depression: 20.0% [15.7-25.2]; general distress: 32.4% [22.7-44.0]). Poorer parent mental health was significantly associated with the presence of chronic pain (anxiety: OR = 1.91 [1.51-2.41]; depression: OR = 1.90 [1.51-2.38]; general distress: OR = 1.74 [1.47-2.05]) and worse related functioning (ie, pain intensity, physical functioning, anxiety and depression symptoms; rs = 0.10-0.25, all Ps < 0.05) in children. Moderator analyses were generally nonsignificant or could not be conducted because of insufficient data. Findings support the importance of addressing parent mental health in the prevention and treatment of pediatric chronic pain.

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Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission

Abstract: Background: Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission.

Cited by 3 publications

References 29 publications

Clinical Hypnosis for Pediatric Gastrointestinal Disorders

Clinical Hypnosis for Pediatric Gastrointestinal Disorders

Prevalence of irritable bowel syndrome and functional abdominal pain disorders in children with inflammatory bowel disease in remission

The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis

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