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Cited by 17 publications
(17 citation statements)
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References 27 publications
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“…The association of LAG3 deficiency with increased CVD risk was also observed in a recent clinical study. Zhu et al [43] observed that Chinese patients with documented coronary artery disease demonstrated significantly lower expression by flow cytometry of CD49b + LAG3 + Tregs (Tr1) cells compared with control subjects. This immunosuppressive Treg subset has been characterized by the surface expression of LAG3 and a source of IL-10 secretion [44][45][46][47].…”
Section: Observational Studies Of High Hdl-c Results From Studies Like the Cardiovascular Health In Ambulatory Care Researchmentioning
confidence: 99%
“…The association of LAG3 deficiency with increased CVD risk was also observed in a recent clinical study. Zhu et al [43] observed that Chinese patients with documented coronary artery disease demonstrated significantly lower expression by flow cytometry of CD49b + LAG3 + Tregs (Tr1) cells compared with control subjects. This immunosuppressive Treg subset has been characterized by the surface expression of LAG3 and a source of IL-10 secretion [44][45][46][47].…”
Section: Observational Studies Of High Hdl-c Results From Studies Like the Cardiovascular Health In Ambulatory Care Researchmentioning
confidence: 99%
“…generated in vitro can be purified from bulk cultures using CD49b and LAG-3 antibodies (Amodio et al, 2015;Gagliani et al, 2013b;Mfarrej et al, 2017;Petrelli et al, 2015). The frequency of CD4 + CD45RA -CD49b + LAG-3 + cells correlates with the expression of IL-10 in human (Amodio et al, 2015;Mfarrej et al, 2017;Petrelli et al, 2015;Sutavani et al, 2013;Tousa et al, 2017;Yao et al, 2015;Tousa et al, 2017), and with induction of immunological tolerance in different preclinical and clinical settings Gagliani et al, 2013b;Kim et al, 2018;Koch et al, 2015;Zhu et al, 2018). Using single-cell mass cytometry, we have shown that CD49b and LAG-3 were sufficient to identify a population of CD4 + CD45RAcells, which is distinct from Th1, Th2, Th17, Tfh, and Treg cells.…”
Section: Phenotype Of Murine and Human Tr1 Cellsmentioning
confidence: 99%
“…Next, a perturbed regulatory microenvironment was noticed in CAD patients that was reflected by lowered IL-10 cytokine secretion, where a decreased blood frequency of regulatory T cell type 1 (Tr1), characterized by cell surface molecules, CD4 + CD49 + LAG3 + CD45RO + T cells, was evident [134]. These CAD-specific Tr1 cells were incapable of mediating the suppressive effects on conventional T cells, mainly through IL-10-dependent manner.…”
Section: Pd-1/pd-l1 Axis In Human Atherosclerosismentioning
confidence: 99%