2018
DOI: 10.1016/j.aquaculture.2018.01.020
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Fumonisins B1 + B2 change the expression of genes in apoptosis balance in Nile tilapia fingerlings

Abstract: In this study, we tested the hypothesis that the ingestion of feed containing fumonisin affects the apoptosis balance in liver cells. Thus, a trial was conducted with Nile tilapia fingerlings (2.64 ± 0.06 g) fed diets containing increasing levels of fumonisin (FB) (0-control diet, 20, 40, and 60 mg/kg), and expression of caspase7 (CASP7) and sphingosine phosphate lyase (SPL) genes in liver tissue was evaluated at 15 and 30 days of treatment. SPL:CASP7 mRNA ratio was also evaluated. Relative mRNA levels of SPL … Show more

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Cited by 7 publications
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“…Other sphinganine-analog mycotoxins (SAMTs) have been reported to induce genotoxic effects in vivo in several publications [ 24 , 25 , 26 , 27 , 28 , 29 ]. However, positive results were either observed only at the highest dose [ 30 ], through a different route of administration (in vitro or in non-mammal species) [ 26 , 28 ], or after a longer period of treatment [ 30 ]. One of the most studied SAMTs, fumonisin B1 (FB1) induced DNA damage in rat spleen cells using the comet assay in a study conducted by Theumer and his collaborators [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Other sphinganine-analog mycotoxins (SAMTs) have been reported to induce genotoxic effects in vivo in several publications [ 24 , 25 , 26 , 27 , 28 , 29 ]. However, positive results were either observed only at the highest dose [ 30 ], through a different route of administration (in vitro or in non-mammal species) [ 26 , 28 ], or after a longer period of treatment [ 30 ]. One of the most studied SAMTs, fumonisin B1 (FB1) induced DNA damage in rat spleen cells using the comet assay in a study conducted by Theumer and his collaborators [ 30 ].…”
Section: Discussionmentioning
confidence: 99%