Fumonisin contamination of commercial corn-based human foodstuffs

Sydenham, Eric W.; Shephard, Gordon S.; Thiel, Pieter G.; Marasas, Walter F. O.; Stockenström, Sonja

doi:10.1021/jf00011a028

Cited by 288 publications

(155 citation statements)

References 29 publications

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“…Since their factory. discovery, various authors have shown that fumonisins cause Using a strain isolated in this laboratory from French several animal diseases, often implicating F. moniliforme, maize, we have shown that mycelial growth, as reflected by which is frequently found in the fungal flora on cereals, in ergosterol levels (Cahagnier 1984), and the biosynthesis of France and elsewhere (Norred 1993;Scott 1993). The most FB1, are greater at higher values (unity) of the water activity abundant and toxic is FB1, which has been shown to induce (a w ) of the substrate (Cahagnier et al 1995).…”

Section: Fumonisins Are Mycotoxins Produced By Fusarium Moni-mentioning

confidence: 57%

Study of the biosynthesis of fumonisins B1, B2 and B3 by different strains of Fusarium moniliforme

Melcion¹,

Cahagnier²,

Richard-Molard³

1997

Letters in Applied Microbiology

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The relationship between fungal growth and the production of fumonisin on maize grain by 25 strains of Fusarium moniliforme of different origins has been investigated. Although sporulation was essentially the same for all the strains (about 108 propagules g−1 dry matter), ergosterol assays revealed marked variations in fungal biomass. All strains studied produced highly variable amounts of fumonisin B1, the highest levels being observed in strains of ergosterol content above 400 μg g−1. However, no correlation could be established between the synthesized biomass and the quantity of fumonisins produced. We verified that ergosterol is an indicator of mycelial growth, and therefore of the potential toxicity of the analysed grain.

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Section: Fumonisins Are Mycotoxins Produced By Fusarium Moni-mentioning

confidence: 57%

Study of the biosynthesis of fumonisins B1, B2 and B3 by different strains of Fusarium moniliforme

Melcion¹,

Cahagnier²,

Richard-Molard³

1997

Letters in Applied Microbiology

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“…There is no direct evidence of FB 1 carcinogenic effect in humans, but an increase of oesophageal cancer is observed in areas where maize, either contaminated by Fusarium or containing high levels of FB 1 , is used as the main staple 5,50 . Fumonisins, mainly FB 1 , have been detected in a large array of maize products in all areas of the world where analyses of such commodities have been conducted 4,6,7,16,17,25,40,45 .…”

Section: Introductionmentioning

confidence: 99%

Fumonisin B1 and ochratoxin A in beers made in Brazil

Kawashima¹,

Vieira²,

Soares³

2007

Ciênc. Tecnol. Aliment.

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Samples of beer made in Brazil were analyzed for the presence of fumonisin B 1 (FB 1 ) and ochratoxin A (OTA). FB 1 was searched for in 58 beer samples from 30 plants located in nine states. The samples were concentrated and cleaned up with strong ion exchange column, derivatized with OPA and analyzed by HPLC with fluorescence detection. The limit of detection was 0.26 ng.mL -1 and the average recovery was 98%. Twenty-five samples contained FB 1 ranging from 1 to 40 ng.mL -1 . Beer (123 samples) from 36 plants located in 5 states were analyzed for OTA by means of immunoaffinity column cleanup followed by liquid chromatography associated with fluorescence. The detection limit was 0.1 ng.mL -1 and the average recovery was 92%. Five samples contained OTA in concentrations from 1 to 18 ng.mL -1 . The results indicate that FB 1 and OTA contamination in Brazilian beer is not geographically limited and that beer does not contribute significantly to FB 1 intake by consumers. In the case of regular high ingestion, beer could contribute sizably to OTA, intake although still below the maximum considered tolerable for the toxin. Keywords: mycotoxins; fumonisin B 1 ; ochratoxin A; beer. ResumoA presença de fumonisina B 1 (FB 1 ) e de ocratoxina A (OTA) foi investigada em amostras de cerveja fabricada no Brasil. FB 1 foi pesquisada em 58 amostras de cerveja provenientes de 30 fábricas localizadas em nove Estados. As amostras foram concentradas, e a toxina isolada através de coluna de troca iônica forte, derivação com OPA e análise por CLAE com fluorescência associada. O limite de detecção foi 0,26 ng.mL -1 e a recuperação média foi de 98%. Vinte e cinco amostras continham FB 1 em concentrações de 1 a 40 ng.mL -1 . Cerveja (123 amostras) proveniente de 36 fábricas localizadas em 5 Estados foi analisada para OTA através de coluna de imunoafinidade seguida de CLAE com detector de fluorescência. O limite de detecção foi 0,1 ng.mL -1 e a recuperação média foi de 92%. Cinco amostras continham OTA em concentrações de 1 a 18 ng.mL -1 . Os resultados indicam que a contaminação da cerveja brasileira por FB 1 e por OTA não é geograficamente limitada e que não contribui significativamente para a ingestão de FB 1 por consumidores. Por outro lado, no caso de consumo alto e regular, esta pode contribuir substancialmente na ingestão de OTA, porém ainda abaixo do máximo considerado tolerável para a toxina. Palavras-chave: micotoxinas; fumonisina B 1 ; ocratoxina A; cerveja.

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“…[101][102][103][104][105][106][107][108][109]. Poultry feed investigated in china was contaminated with 1854.3mg/kg (37).…”

Section: Occurrence Of Fumonisinmentioning

confidence: 99%