volume 27, issue 1, P143-153 2011
DOI: 10.3233/jad-2011-110623
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Alberto Cornejo, José M. Jiménez, Leonardo Caballero, Francisco Melo, Ricardo B. Maccioni

Abstract: Alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau protein. Recently, tangle formation has been identified as a major event involved in the neurodegenerative process, due to the conversion of either soluble peptides or oligomers into insoluble filaments. At present, the current therapeutic strategies are aimed at natural phytocomplexes and polyphenolics compounds able to either inhibit the formation of tau filaments or disaggregate t…

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