2003
DOI: 10.1016/s0731-7085(03)00186-9
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Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up

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Cited by 44 publications
(14 citation statements)
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“…The mean pore diameter of the silica particles is also about 6 nm and the external surface is biocompatible. This support, namely XDS (SO 3 /diol) sorbent, presents the properties of a strong cation exchanger towards basic compounds and has been evaluated in our previous works [20,21] for on-line sample handling prior to the LC determination of some basic compounds in plasma.…”
Section: Introductionmentioning
confidence: 99%
“…The mean pore diameter of the silica particles is also about 6 nm and the external surface is biocompatible. This support, namely XDS (SO 3 /diol) sorbent, presents the properties of a strong cation exchanger towards basic compounds and has been evaluated in our previous works [20,21] for on-line sample handling prior to the LC determination of some basic compounds in plasma.…”
Section: Introductionmentioning
confidence: 99%
“…[170][171][172] There are a variety of considerations to ensure the design of a successful RAM, namely:…”
Section: Theory Of Rammentioning
confidence: 99%
“…32 Other miniaturization efforts driven by the need to handle small sample volumes led to the development of pipette tip configurations, membrane extraction by packed sorbent (MEPS) and fiber-in-tube SPE (FIT-SPE). 19,[33][34][35] Over the years, significant progress has been made in the search of new materials for SPE. 13,[36][37][38] On the contrary, the development of new SPE formats has been very slow.…”
Section: Introductionmentioning
confidence: 99%