Full-Thickness Eye Wall Resection

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

“…The composition of the photoreceptor mosaic of patients with NR2E3 disease has previously been largely inferred from electroretinogram testing and clinical imaging (31)(32)(33)(34). Postmortem studies of patient eyes affected by NR2E3 disease have been limited to broad cone cytoplasmic markers, structural electron microscopy, and opsin staining (12,35,36). These studies have shown that an increased number of short wavelength opsin-expressing cells exist in NR2E3 patient retina and that no rhodopsin expressing cells are present.…”

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

“…The composition of the photoreceptor mosaic of patients with NR2E3 disease has previously been largely inferred from electroretinogram testing and clinical imaging (31)(32)(33)(34). Postmortem studies of patient eyes affected by NR2E3 disease have been limited to broad cone cytoplasmic markers, structural electron microscopy, and opsin staining (12,35,36). These studies have shown that an increased number of short wavelength opsin-expressing cells exist in NR2E3 patient retina and that no rhodopsin expressing cells are present.…”

Local Resection in Choroidal Melanoma: A Review

“…Foulds described a technique consisting of scleral lamellar dissection at the base of the tumour, removal of the deep scleral lamella attached to the tumour, and finally microsurgical excision of the tumour followed by closure of the defect through the external scleral lamella [33]. This technique was later modified and improved by other surgeons, which greatly expanded the use of this technique, which became known as partial lamellar sclerouvectomy (PLSU) [8,9,13,[34][35][36][37].…”

“…Peyman et al described a procedure [34,38] that was similar to that developed by Meyer-Schwickerath [39]. This technique consisted of en bloc resection of the tumour and the scleral wall after intense photocoagulation and diathermy around the base of the tumour, followed by closure of the defect with a scleral graft.…”

“…Metastatic death was not significantly associated with incomplete tumour excision or small residual/recurrent tumours treated by enucleation. In a previous study carried out by the same group of authors [34], the risk of metastatic death was based on the number of risk factors present: (1) basal tumour diameter > 15.4 mm; (2) tumour extension anterior to the ora serrata; and (3) presence of epithelioid cells. In that study, metastatic death at 16 years was 20.2% if none of these risk factors was present, 32.5% with one risk factor, and 46.7% with two risk factors [10,37].…”

Primary Intraocular Lymphoma: The Masquerade Syndrome

“…Failure to identify malignant cells in the vitreous can occur and may be due to degeneration of the cells in samples, paucity of cells into the vitreous cavity, or lack of vitreal involvement. Indeed, lymphomatous cells may be confined solely to the sub-RPE and, in this case, an external chorioretinal biopsy (pioneered by Peyman and colleagues) may lead to a definitive diagnosis of PIOL [59][60][61][62].…”

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

“…The composition of the photoreceptor mosaic of patients with NR2E3 disease has previously been largely inferred from electroretinogram testing and clinical imaging (31)(32)(33)(34). Postmortem studies of patient eyes affected by NR2E3 disease have been limited to broad cone cytoplasmic markers, structural electron microscopy, and opsin staining (12,35,36). These studies have shown that an increased number of short wavelength opsin-expressing cells exist in NR2E3 patient retina and that no rhodopsin expressing cells are present.…”

Local Resection in Choroidal Melanoma: A Review

“…Foulds described a technique consisting of scleral lamellar dissection at the base of the tumour, removal of the deep scleral lamella attached to the tumour, and finally microsurgical excision of the tumour followed by closure of the defect through the external scleral lamella [33]. This technique was later modified and improved by other surgeons, which greatly expanded the use of this technique, which became known as partial lamellar sclerouvectomy (PLSU) [8,9,13,[34][35][36][37].…”

“…Peyman et al described a procedure [34,38] that was similar to that developed by Meyer-Schwickerath [39]. This technique consisted of en bloc resection of the tumour and the scleral wall after intense photocoagulation and diathermy around the base of the tumour, followed by closure of the defect with a scleral graft.…”

“…Metastatic death was not significantly associated with incomplete tumour excision or small residual/recurrent tumours treated by enucleation. In a previous study carried out by the same group of authors [34], the risk of metastatic death was based on the number of risk factors present: (1) basal tumour diameter > 15.4 mm; (2) tumour extension anterior to the ora serrata; and (3) presence of epithelioid cells. In that study, metastatic death at 16 years was 20.2% if none of these risk factors was present, 32.5% with one risk factor, and 46.7% with two risk factors [10,37].…”

Primary Intraocular Lymphoma: The Masquerade Syndrome

“…Failure to identify malignant cells in the vitreous can occur and may be due to degeneration of the cells in samples, paucity of cells into the vitreous cavity, or lack of vitreal involvement. Indeed, lymphomatous cells may be confined solely to the sub-RPE and, in this case, an external chorioretinal biopsy (pioneered by Peyman and colleagues) may lead to a definitive diagnosis of PIOL [59][60][61][62].…”

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

“…The composition of the photoreceptor mosaic of patients with NR2E3 disease has previously been largely inferred from electroretinogram testing and clinical imaging (31)(32)(33)(34). Postmortem studies of patient eyes affected by NR2E3 disease have been limited to broad cone cytoplasmic markers, structural electron microscopy, and opsin staining (12,35,36). These studies have shown that an increased number of short wavelength opsin-expressing cells exist in NR2E3 patient retina and that no rhodopsin expressing cells are present.…”

Local Resection in Choroidal Melanoma: A Review

“…Foulds described a technique consisting of scleral lamellar dissection at the base of the tumour, removal of the deep scleral lamella attached to the tumour, and finally microsurgical excision of the tumour followed by closure of the defect through the external scleral lamella [33]. This technique was later modified and improved by other surgeons, which greatly expanded the use of this technique, which became known as partial lamellar sclerouvectomy (PLSU) [8,9,13,[34][35][36][37].…”

“…Peyman et al described a procedure [34,38] that was similar to that developed by Meyer-Schwickerath [39]. This technique consisted of en bloc resection of the tumour and the scleral wall after intense photocoagulation and diathermy around the base of the tumour, followed by closure of the defect with a scleral graft.…”

“…Metastatic death was not significantly associated with incomplete tumour excision or small residual/recurrent tumours treated by enucleation. In a previous study carried out by the same group of authors [34], the risk of metastatic death was based on the number of risk factors present: (1) basal tumour diameter > 15.4 mm; (2) tumour extension anterior to the ora serrata; and (3) presence of epithelioid cells. In that study, metastatic death at 16 years was 20.2% if none of these risk factors was present, 32.5% with one risk factor, and 46.7% with two risk factors [10,37].…”

Primary Intraocular Lymphoma: The Masquerade Syndrome

“…Failure to identify malignant cells in the vitreous can occur and may be due to degeneration of the cells in samples, paucity of cells into the vitreous cavity, or lack of vitreal involvement. Indeed, lymphomatous cells may be confined solely to the sub-RPE and, in this case, an external chorioretinal biopsy (pioneered by Peyman and colleagues) may lead to a definitive diagnosis of PIOL [59][60][61][62].…”