Full-length MSP1 is a major target of protective immunity after controlled human malaria infection
Micha Rosenkranz,
Irene N Nkumama,
Rodney Ogwang
et al.
Abstract:The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the invasive merozoite stages ofPlasmodium falciparumand has long been considered a key target of protective immunity. We used samples from a single controlled human malaria challenge study to test whether the full-length version of MSP1 (MSP1FL) induced antibodies that mediated Fc-IgG functional activity in five independent assays. We found that anti-MSP1FLantibodies induced complement fixation via C1q, monocyte-mediated pha… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.