Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus

Bailey, Dalan; Banyard, Ashley C.; Dash, Pradyot; Özkul, Aykut; Barrett, Tom

doi:10.1016/j.virusres.2005.01.013

Cited by 182 publications

(135 citation statements)

References 38 publications

Supporting

Mentioning

125

Contrasting

Order By: Relevance

“…Molecular detection and characterization of the virus was done by Özkul et al (2002), and 2 virus isolates were reported in lineage IV. The full genome sequence of 1 of these PPR viruses isolated in Turkey was determined by Bailey et al (2005).…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic analysis of peste des petits ruminants virus from outbreaks in Turkey during 2008–2012

Guler¹,

Şevik²,

Hasöksüz³

2014

Turk J Biol

View full text Add to dashboard Cite

Peste des petits ruminants (PPR) is an important viral disease of sheep and goats and is endemic in all regions of Turkey. In this study, PPR virus infection was investigated by RT-PCR assay based on the fusion (F) gene in PPR-suspected sheep and goat samples. PPR virus RNA was detected in 65 small ruminants (51 sheep, 14 goats) from independent outbreaks during [2008][2009][2010][2011][2012] in provinces in the central and Mediterranean regions and the central-west part of the Aegean region in Turkey. The virus was detected in an aborted sheep fetus sample by RT-PCR, and diagnosis was also confirmed by virus isolation. Vaccine strain Nigeria 75/1 was differentiated from field isolates by restriction fragment length polymorphism analysis of RT-PCR products using EcoRI. Phylogenetic analysis of 16 viruses indicated that all viruses, including the one from the aborted sheep fetus, belonged to lineage IV, as had the PPR viruses previously isolated in Turkey. Nucleotide sequence identity among 16 viruses was 99.1%-100%. Results showed that PPR virus lineage IV has been in circulation in Turkey since the first detection of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Phylogenetic analysis of peste des petits ruminants virus from outbreaks in Turkey during 2008–2012

Guler¹,

Şevik²,

Hasöksüz³

2014

Turk J Biol

View full text Add to dashboard Cite

show abstract

“…Logically, however, it may be beneficial to plan strategically for entire genome sequencing, to allow detailed monitoring of any ongoing PPRV epidemic. This genome-wide approach was shown recently to be essential for identifying the origin of a measles outbreak at the 2010 Vancouver Winter Olympic Games [76][77][78]; furthermore, full PPRV genome sequences, including vaccine sequences, are already available to support this effort [79,80] (Table 1 and Fig. 2).…”

Section: Novel Tools In the Pipelinementioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

show abstract

“…The genome is a negative sense single stranded-RNA, approximately 16 Kilo bases (kb) long with negative polarity [29]. The genes are arranged in the order of 3 0 N-P/C/V-M-F-H-L 5 0 [6,46] and separated by inter-genic region [46] and the nucleotides follows the ''rule-of-six'' [19]. It is divided into six transcriptional units encoding two non-structural proteins (V, C) and six structural proteins: the surface glycoproteins which include fusion (F) and Haemagglutinin (H) proteins, the matrix protein (M), the nucleoprotein (N), and the phosphoprotein (P) which forms the polymerase complex in association with large (L) protein [36,42,61,129].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

130

118

View full text Add to dashboard Cite

Peste des petits ruminants (PPR) is an acute, highly contagious, world organization for animal health (OIE) notifiable and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality and caused by PPR virus. PPR is considered as one of the main constraints in augmenting the productivity of small ruminants in developing countries and particularly severely affects poor farmer's economy. The disease is clinically manifested by pyrexia, oculo-nasal discharges, necrotizing and erosive stomatitis, gastroenteritis, diarrhoea and bronchopneumonia. The disease can be diagnosed from its clinical signs, pathological lesions, and specific detection of virus antigen/antibodies/genome in the clinical samples by various serological tests and molecular assays. PPR is the one of the priority animal diseases whose control is considered important for poverty alleviation in enzootic countries. Availability of effective and safe live attenuated cell culture PPR vaccines and diagnostics have boosted the recently launched centrally sponsored control programme in India and also in other countries. This review article primarily focus on the current scenario of PPR diagnosis and its control programme with advancement of research areas that have taken place in the recent years with future perspectives.

show abstract

Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus

Cited by 182 publications

References 38 publications

Phylogenetic analysis of peste des petits ruminants virus from outbreaks in Turkey during 2008–2012

Phylogenetic analysis of peste des petits ruminants virus from outbreaks in Turkey during 2008–2012

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Diagnosis and control of peste des petits ruminants: a comprehensive review

Contact Info

Product

Resources

About