“…4 Although the use of topical lidocaine is considered relatively safe, instances of cardiotoxic and neurotoxic adverse events have been reported. In January 2005, a 22-year-old woman, in excellent health, experienced convulsions, lapsed into a coma, and subsequently died after applying a topical gel containing 10% lidocaine, 10% tetracaine, and an unknown amount of phenylephrine to both legs under occlusion.…”