Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues

Maeda, Hayato; Hosokawa, Masashi; Sashima, Tokutake; Funayama, Katsura; Miyashita, Kazuo

doi:10.1016/j.bbrc.2005.05.002

Cited by 538 publications

(332 citation statements)

References 18 publications

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“…The composition (g/kg diet) of the diets is shown in Table ⅠA. The fatty acid composition of each diet was analyzed by gas chromatography, as previously described (4).…”

Section: Methodsmentioning

confidence: 99%

“…Fucoxanthin is a characteristic carotenoid of brown algae including edible species such as Undaria pinnatifida and Hijikia fusiformis. We recently reported the suppression of the development of white adipose tissue (WaT) by fucoxanthin in obese/diabetic kk-A y mice (4,5). expression of uncoupling protein 1 (ucP1), which plays an important role in energy expenditure, was induced by dietary fucoxanthin in WaT but not in brown adipose tissue; this ucP1 expression was responsible for the antiobesity effect of fucoxanthin.…”

Section: Introductionmentioning

confidence: 99%

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Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Maeda$^{¹

2009

Mol Med Rep

233

166

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Abstract. Fucoxanthin, a characteristic carotenoid of brown algae, has been reported to exert an anti-diabetic effect in an obese murine model. Wakame (Undaria pinnatifida), an edible seaweed, is rich in fucoxanthin. This study examined the anti-obesity and anti-diabetic effects of fucoxanthin-rich wakame lipids (Wls) on high fat (HF) diet-induced obesity in mice. Mice were fed a high fat control (HF c ) or normal fat control (nF c ) diet for 10 weeks. The HF diet-fed group was administered a HF diet containing Wls for a further 5 weeks. Parameters related to diabetes and obesity conditions were evaluated and compared. The HF-Wl diet, which was rich in fucoxanthin, significantly suppressed body weight and white adipose tissue (WaT) weight gain induced by the HF diet. dietary administration of the HF diet resulted in hyperglycemia, hyperinsulinemia and hyperleptinemia in the mouse model. These perturbations were completely normalized in the HF-Wl diet-fed group. increased expression of monocyte chemoattractant protein-1 (McP-1) mrna expression was observed in HF c mice, but was normalized in the HF-Wl groups. Moreover, the HF-Wl diet promoted mrna expression of β3-adrenergic receptor (adrb3) in WaT and glucose transporter 4 (gluT4) mrna in skeletal muscle tissues. These results suggest that dietary Wls may ameliorate alterations in lipid metabolism and insulin resistance induced by a HF diet. There is therefore a biochemical and nutritional basis for the application of fucoxanthin-rich Wls as a functional food to prevent obesity and diabetes-related disorders. IntroductionThe modern-day tendency to consume nutritionally rich diets coupled with irrational dietary habits create physiological disorders. These lead to the accumulation of visceral fat, and finally result in obesity and related disorders, such as diabetes mellitus, hypertension, dyslipidemia and cardiovascular disease (1,2). long-term consumption of a high fat (HF) diet accelerates the development of obesity (3); hence, strategies to prevent obesity are of great importance. Fucoxanthin is a characteristic carotenoid of brown algae including edible species such as Undaria pinnatifida and Hijikia fusiformis. We recently reported the suppression of the development of white adipose tissue (WaT) by fucoxanthin in obese/diabetic kk-A y mice (4,5). expression of uncoupling protein 1 (ucP1), which plays an important role in energy expenditure, was induced by dietary fucoxanthin in WaT but not in brown adipose tissue; this ucP1 expression was responsible for the antiobesity effect of fucoxanthin. Furthermore, dietary fucoxanthin regulated adipocytokine secretion, thus preventing hyperglycemia in a type 2 diabetes kk-A y mouse model (5). The adipocyte as an endocrine cell has recently been recognized for its role in the secretion of biologically active mediators, termed adipokines/chemokines, including leptin, adiponectin, resistin, tumor necrosis factor-α (TnF-α) and monocyte chemoattractant protein-1 (McP-1) (6-8). Some adipokines are reported to alter insulin...

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“…The composition (g/kg diet) of the diets is shown in Table ⅠA. The fatty acid composition of each diet was analyzed by gas chromatography, as previously described (4).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Maeda$^{¹

2009

Mol Med Rep

233

166

View full text Add to dashboard Cite

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“…The interscapular BAT was homogenized in a solution containing 10 mM Tris-HCl and 1 mM EDTA (pH 7.4). After centrifugation (1,500 g for 5 min, at 4°C), the fat cake was discarded and the middle layer (fat-free extract) was used for Western blotting [13]. The fat-free extract was added to the sodium dodecyl sulfate (SDS) sample buffer.…”

Section: Methodsmentioning

confidence: 99%

Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-α-like effector A, in rat interscapular brown adipose tissue by sympathetically activated β3-adrenoreceptors

Shimizu

Yokotani

2009

Biochemical and Biophysical Research Communications

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The thermogenic activity of brown adipose tissue (BAT) largely depends on the mitochondrial uncoupling protein 1 (UCP1), which is up-regulated by environmental alterations such as cold. Recently, CIDEA (cell death-inducing DNA fragmentation factor--like effector A) has also been shown to be expressed at high levels in the mitochondria of BAT. Here we examined the effect of cold on the mRNA and protein levels of CIDEA in interscapular BAT of conscious rats with regard to the sympathetic nervous system. Cold exposure (4°C for 3 h) elevated the plasma norepinephrine level and increased norepinephrine-turnover in BAT. Cold exposure resulted in downregulation of the mRNA and protein levels of CIDEA in BAT, accompanied by upregulation of mRNA and protein levels of UCP1. The cold exposure-induced changes of CIDEA and UCP1 were attenuated by intraperitoneal pretreatment with propranolol (a non-selective β-adrenoreceptor antagonist) (2 mg/animal) or SR59230A (a selective β 3 -adrenoreceptor antagonist) (2 mg/animal), respectively. These results suggest that acute cold exposure resulted in down-regulation of CIDEA in interscapular BAT by sympathetically activated β 3 -adrenoreceptor-mediated mechanisms in rats.

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“…The fucoxanthin contents of T. turbinata was found to be 0.59 ± 0.08 mg/gm dry-weight. Ultraviolet spectrum of fucoxanthin showed the maximum absorbance at 450 nm 40 .…”

Section: Fucoxanthins From Turbinaria Speciesmentioning

confidence: 99%

“…Ellya sinurat et al has reported to have isolated 2.6% fucoidans from Tubinaria sp. Anti-lipidemic activity has been reported in Fucoidans extracted from Undaria pinnatifida these fucoidans were found to affect the mRNA gene expression of key adipogenic markers and expression of inflammation-related genes in adipocyte cells during adipogenesis 40,44 .…”

Section: Fucoxanthins From Turbinaria Speciesmentioning

confidence: 99%

Manifestation of Metabolic Syndrome by Turbinaria Species: A Review

Mishra¹,

Kumar²,

Juyal³

et al. 2017

Int. Res. J. Pharm.

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Metabolic disorder refers to a cluster of metabolic abnormalities (i.e., insulin resistance, hypertension, dyslipidemia, obesity, high cholesterol and high blood pressure). The metabolic disorder is fast becoming a global emergency. Drugs presently available in the market help in curing the disorder only up to some extent and providing symptomatic relief, in lieu of an array of side effects, hence it is the need of the hour to look for alternative strategy for prevention and treatment of metabolic syndrome. Marine natural products are a source of antihypertensive, antihyperglycemic, antioxidative, and anticancer agents possibly useful in the treatment or in the prevention of metabolic disorders. Through this review we have made an effort to throw some light on potential uses of the marine sea weed, a genus of brown algae Turbinaria (Phaeophyceae) as a potential agent for the treatment and amelioration of metabolic syndrome and related disorder, we have briefed about various chemical constituents found in the different species of Turbinaria and the role they can play in achieving the above said goal.

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Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues

Cited by 538 publications

References 18 publications

Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-α-like effector A, in rat interscapular brown adipose tissue by sympathetically activated β3-adrenoreceptors

Manifestation of Metabolic Syndrome by Turbinaria Species: A Review

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