Fucoxanthin as a major carotenoid in Isochrysis aff. galbana: Characterization of extraction for commercial application

Kim, Sang Min; Kang, Sukwoo; Kwon, O-Nam; Chung, Donghwa; Pan, Cheol‐Ho

doi:10.1007/s13765-012-2108-3

Cited by 181 publications

(111 citation statements)

References 26 publications

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“…The limited availability of natural fucoxanthin to date is not only due to the lack of sufficient supply of fucoxanthin-rich biomass feedstock, but also poor extraction efficiency of fucoxanthin from biomass [5,26]. In order to determine the optimal conditions for fucoxanthin extraction, five conventional solvents were tested to determine the most suitable solvent for extraction of fucoxanthin from O .…”

Section: Resultsmentioning

confidence: 99%

Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita

et al. 2013

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The production, characterization, and antioxidant capacity of the carotenoid fucoxanthin from the marine diatom Odontella aurita were investigated. The results showed that low light and nitrogen-replete culture medium enhanced the biosynthesis of fucoxanthin. The maximum biomass concentration of 6.36 g L−1 and maximum fucoxanthin concentration of 18.47 mg g−1 were obtained in cultures grown in a bubble column photobioreactor (Ø 3.0 cm inner diameter), resulting in a fucoxanthin volumetric productivity of 7.96 mg L−1 day−1. A slight reduction in biomass production was observed in the scaling up of O. aurita culture in a flat plate photobioreactor, yet yielded a comparable fucoxanthin volumetric productivity. A rapid method was developed for extraction and purification of fucoxanthin. The purified fucoxanthin was identified as all-trans-fucoxanthin, which exhibited strong antioxidant properties, with the effective concentration for 50% scavenging (EC50) of 1,1-dihpenyl-2-picrylhydrazyl (DPPH) radical and 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical being 0.14 and 0.03 mg mL−1, respectively. Our results suggested that O. aurita can be a natural source of fucoxanthin for human health and nutrition.

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Section: Resultsmentioning

confidence: 99%

Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita

et al. 2013

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“…It is found abundantly in edible seaweeds such as Undaria pinnatifida , Laminaria digitata and Hijikia fusiformis . In addition, marine microalgae such as Phaeodactylum tricornutum and Isochrysis galbana have been regarded as potential commercial producers of fucoxanthin, as their contents of the pigment are much higher than those of brown seaweeds (Table A2) [39,40]. Fucoxanthin is a potent antioxidant compound, and has potential application for functional food preparation [41,42].…”

Section: Algal Compounds With Anti-obesity Effectsmentioning

confidence: 99%

Marine Algae as a Potential Source for Anti-Obesity Agents

2016

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Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects. Thus, there is a need to look for new anti-obesity agents, especially from biological sources. Marine algae, especially seaweeds are a promising source of anti-obesity agents. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins. The anti-obesity effects of such compounds are due to several mechanisms, which include the inhibition of lipid absorption and metabolism (e.g., fucoxanthin and fucoidans), effect on satiety feeling (e.g., alginates), and inhibition of adipocyte differentiation (e.g., fucoxanthin). Further studies, especially testing bioactive compounds in long-term human trials are required before any new anti-obesity drugs based on algal products can be developed.

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“…Due to the importance of DHA in human health, these two genera are also of interest as a replacement for fish oil, although the high production cost is still prohibitive for large-scale commercial production (Gladyshev et al, 2013). galbana (T-ISO strain) has also been noted for its high content of fucoxanthin (Kim et al, 2012), a pigment that is being investigated for its medical properties in treating cancer, obesity, inflammation, and diabetes (Muthuirulappan and Francis, 2013;Peng et al, 2011). galbana (T-ISO strain) has also been noted for its high content of fucoxanthin (Kim et al, 2012), a pigment that is being investigated for its medical properties in treating cancer, obesity, inflammation, and diabetes (Muthuirulappan and Francis, 2013;Peng et al, 2011).…”

Section: Bioproducts and Bioenergymentioning

confidence: 99%