Fucoidan affects oral squamous cell carcinoma cell functions <i>in vitro</i> by regulating FLNA‐derived circular RNA

Zhang, Nanyang; Gao, Ling; Ren, Wenhao; Li, Shaoming; Zhang, Demeng; Song, Xianqin; Zhao, Chenyang; Zhi, Kangkang

doi:10.1111/nyas.14190

Cited by 21 publications

(20 citation statements)

References 52 publications

(95 reference statements)

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“…CircRNAs play important roles in the carcinogenesis and development of many cancers [27]. Among the researched circRNAs, only circFLNA was reported to be abnormally expressed in human oral and laryngeal squamous cell carcinomas [28][29][30]. In this study, The level of cleaved caspase-3/caspase-3 was analyzed quantitatively in the tissues from mice injected with A549 cells.…”

Section: Discussionmentioning

confidence: 93%

Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1

et al. 2021

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Significantly high-expressed circFLNA has been found in various cancer cell lines, but not in lung cancer. Therefore, this study aimed to explore the role of circFLNA in the progression of lung cancer. The target gene of circFLNA was determined by bioinformatics and luciferase reporter assay. Viability, proliferation, migration, and invasion of the transfected cells were detected by CCK-8, colony formation, wound-healing, and transwell assays, respectively. A mouse subcutaneous xenotransplanted tumor model was established, and the expressions of circFLNA, miR-486-3p, XRCC1, CYP1A1, and related genes in the cancer cells and tissues were detected by RT-qPCR, Western blot, or immunohistochemistry. The current study found that miR-486-3p was low-expressed in lung cancer. MiR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells. Cancer cell viability, proliferation, migration, and invasion were promoted by overexpressed circFLNA, XRCC1, and CYP1A1 but inhibited by miR-486-3p mimic and circFLNA knockdown. The weight of the xenotransplanted tumor was increased by circFLNA overexpression yet reduced by miR-486-3p mimic. Furthermore, miR-486-3p mimic reversed the effect of circFLNA overexpression on promoting lung cancer cells and tumors and regulating the expressions of miR-486-3p, XRCC1, CYP1A1, and metastasis/apoptosis/proliferation-related factors. However, overexpressed XRCC1 and CYP1A1 reversed the inhibitory effect of miR-486-3p mimic on cancer cells and tumors. In conclusion, circFLNA acted as a sponge of miR-486-3p to promote the proliferation, migration, and invasion of lung cancer cells in vitro and in vivo by regulating XRCC1 and CYP1A1.

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Section: Discussionmentioning

confidence: 93%

Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1

et al. 2021

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“…reported that circFLNA is a fucoidan target. They found that fucoidan increased the expression of circFLNA in OSCC cell lines and affected the expression of key proteins related to growth, apoptosis, migration, and invasion ( 39 ).…”

Section: Circrnas Are Widely Expressed and Serve As Markers And Targets In Hncmentioning

confidence: 99%

Research Progress of circRNAs in Head and Neck Cancers

Deng

et al. 2021

Front. Oncol.

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Circular RNAs (circRNAs) are a novel type of non-coding RNAs. Because of their characteristics of a closed loop structure, disease- and tissue-specificity, and high conservation and stability, circRNAs have the potential to be biomarkers for disease diagnosis. Head and neck cancers are one of the most common malignant tumors with high incidence rates globally. Affected patients are often diagnosed at the advanced stage with poor prognosis, owing to the concealment of anatomic sites. The characteristics, functions, and specific mechanisms of circRNAs in head and neck cancers are increasingly being discovered, and they have important clinical significance for the early diagnosis, treatment, and prognosis evaluation of patients with cancer. In this study, the generation, characteristics, and functions of circRNAs, along with their regulatory mechanisms in head and neck cancers have been summarized. We report that circRNAs interact with molecules such as transcription and growth factors to influence specific pathways involved in tumorigenesis. We conclude that circRNAs have an important role to play in the proliferation, invasion, metastasis, energy and substance metabolism, and treatment resistance in cancers.

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“…The analysis of glycosidic bonds showed that (1,3)-α-1-ethyl fuco-pyranose (31.9%) was the main residue, followed by 1,2-linked (13.2%) and 1,4-linked (7.7%) fucose and highly branched (22.4%). A large number of studies have shown that fucoidan induces cytotoxicity towards various types of cancer cell, induces apoptosis and inhibits the invasion, metastasis and angiogenesis of cancer cells [48][49][50][51][52][53][54][55][56][57][58]. Damonte et al discussed the structure of alginate in detail along with its biological functions in the mechanisms of apoptosis, invasion, metastasis, angiogenesis and the growth and signaling of cancer cell growth, which proved the medicinal value of these alginoglycans [59].…”

Section: Structure and Characteristics Of Other Seaweed Polysaccharidesmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

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Fucoidan affects oral squamous cell carcinoma cell functions in vitro by regulating FLNA‐derived circular RNA

Cited by 21 publications

References 52 publications

Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1

Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1

Research Progress of circRNAs in Head and Neck Cancers

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

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