FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes

Al-Zoubi, Nizar; Koundourellis, John E.; Malamataris, S.

doi:10.1016/s0731-7085(02)00098-5

Cited by 131 publications

(83 citation statements)

References 13 publications

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“…8 Since the FT-Raman and micro-Raman techniques have begun to be used in the study of pharmaceutics only recently, a limited number of studies currently exist in the literature. [28][29][30][31][32][33][34] Before now, mapping has been used in only 1 study of solid dispersion systems. 22 The preparation and storage conditions of the solid dispersions play a critical role, as changes may alter the dissolution characteristics of the active ingredients over time.…”

Section: Characterization Of Solid Dispersionsmentioning

confidence: 99%

Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder x-ray diffraction

Docoslis

Huszarik

Papageorgiou

et al. 2007

AAPS J

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In the present study, a series of solid dispersions of the drug nimodipine using polyethylene glycol as carrier were prepared following the hot-melt method. Micro-Raman spectroscopy in conjunction with X-ray powder diffractometry was used for the characterization of the solid structure, including spatial distribution, physical state, and presence of polymorphs, as well as storage stability of nimodipine in its solid formulations. The effect of storage time on drug stability was investigated by examination of the samples 6 months and 18 months after preparation. Confocal microRaman mapping performed on the samples showed that the drug was not uniformly distributed on a microscopic level. The presence of crystals of nimodipine with sizes varying between one and several micrometers was detected, and the crystal size seemed to increase with overall drug content. In samples examined 6 months after preparation it was found that the crystals existed mainly as the racemic compound, whereas after 18 months of storage mainly crystal conglomerates were observed.

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Section: Characterization Of Solid Dispersionsmentioning

confidence: 99%

Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder x-ray diffraction

Docoslis

Huszarik

Papageorgiou

et al. 2007

AAPS J

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“…Spectrophotometry [9], chemiluminescence [10], capillary electrophoresis [11], FT-IR and Raman spectroscopy [12] and chromatography [13] methods have been employed for the determination of PA. However, these methods have several disadvantages such as high costs, long analysis time, requirement for sample pretreatment, low sensitivity and selectivity that makes them unsuitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Selective Electrochemical Determination of Paracetamol Using Nanostructured Film of Functionalized Thiadiazole Modified Electrode

Kalimuthu

John

2010

Electroanalysis

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This paper describes the selective electrochemical determination of paracetamol (PA) in the presence of important interferent, ascorbic acid (AA) using an ultrathin electropolymerized film of 5-amino-1,3,4-thiadiazole-2-thiol (p-ATT) modified glassy carbon (GC) electrode in 0.20 M phosphate buffer solution (pH 7.20). Bare GC electrode failed to resolve the voltammetric signals of AA and PA in a mixture. On the other hand, the p-ATT modified electrode not only separated the voltammetric signals of AA and PA but also enhanced their peak currents. We achieved the lowest detection limit of 0.34 nM (S/N ¼ 3) for PA at p-ATT modified electrode.

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“…28 Such examples are the quantitative analysis of diltiazem hydrochloride in commercially available tablets (Tildiem) 28 and the identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes. 17,29 The mapping facility of an FT-Raman microscope was used to construct a profile of oestradiol distribution in a transdermal drug delivery device, demonstrating the advantages for determining the homogeneity of components in a complex system. 30 Another comprehensive FT-Raman study 31 recently demonstrated the potential of this technique to probe the solid-state form of active substances present in tablets and capsules.…”

Section: Ft-ramanmentioning

confidence: 99%

Identification and characterization of pharmaceuticals using Raman and surface‐enhanced Raman scattering

Pinzaru

Pavel

Leopold

et al. 2004

J Raman Spectroscopy

129

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Many recent papers reflect ongoing research and development concerning pharmaceutical applications of Raman techniques. This short review highlights different Raman techniques (dispersive, Fourier transform, resonance Raman, SERS, SERRS, FT-SERS) employed in pharmaceutical investigations. Several Raman applications such as fundamental structural investigations, quantitative analysis, drug-excipient interaction, formulation, limit of detection, pH-dependent pharmaceutical species, adsorption geometry at a given surface and functional groups involved in adsorption for several widely used pharmaceutical compounds are presented.

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FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes

Cited by 131 publications

References 13 publications

Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder x-ray diffraction

Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder x-ray diffraction

Selective Electrochemical Determination of Paracetamol Using Nanostructured Film of Functionalized Thiadiazole Modified Electrode

Identification and characterization of pharmaceuticals using Raman and surface‐enhanced Raman scattering

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