FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway

Zhang, Mengqi; Wang, Yan; Huan, Zhikun; Liu, Yaping; Zhang, Wenwen; Kong, Dehuan; Kong, Ling-Dong; Xu, Jin

doi:10.1007/s00774-021-01232-3

Cited by 7 publications

(1 citation statement)

References 41 publications

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“…), FSHR expression was much higher than gonadotropin cells [18]. Also, chondrocyte-like ATDC5 cells expressed functional FSHRs [19]. Interestingly, our data using RNAscope showed FSHR expressions in cerebral cortex and hippocampus, particularly in granular layer and pyramidal tract [13]-this suggested a role for FSH-FSHR interactions in cognition.…”

Section: Ubiquitous Expression Of Pituitary Hormone Receptorsmentioning

confidence: 57%

Independent Skeletal Actions of Pituitary Hormones

Sultana¹,

Korkmaz²,

Lizneva³

et al. 2022

Endocrinol Metab

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Over the past years, pituitary hormones and their receptors have been shown to have non-traditional actions that allow them to bypass the hypothalamus-pituitary-effector glands axis. Bone cells-osteoblasts and osteoclasts-express receptors for growth hormone, follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), prolactin, oxytocin, and vasopressin. Independent skeletal actions of pituitary hormones on bone have been studied using genetically modified mice with haploinsufficiency and by activating or inactivating the receptors pharmacologically, without altering systemic effector hormone levels. On another front, the discovery of a TSH variant (TSH-βv) in immune cells in the bone marrow and skeletal action of FSHβ through tumor necrosis factor α provides new insights underscoring the integrated physiology of bone-immune-endocrine axis. Here we discuss the interaction of each pituitary hormone with bone and the potential it holds in understanding bone physiology and as a therapeutic target.

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Section: Ubiquitous Expression Of Pituitary Hormone Receptorsmentioning

confidence: 57%