“…In addition to the cortical thinning of the precentral gyrus, cortical thickness measurements were found to be altered in multiple brain areas encompassing (predominantly right‐sided) frontal, insular, temporal, parietal, and occipital regions in both MND‐motor and MND‐plus patients. The evidence of a distributed involvement of extra‐motor areas in MND confirms recent pathological data [Brettschneider et al, ] and previous neuroimaging studies [Agosta et al, ; d'Ambrosio et al, ; Mezzapesa et al, ; Schuster et al, ; Thorns et al, ; Verstraete et al, ]. In all cortical regions, we found a trend toward a more severe thinning in MND‐plus relative to MND‐motor patients underscoring the morphological continuum within the MND spectrum.…”