Fronto-temporal disconnectivity and symptom severity in children with autism spectrum disorder

Poustka, Luise; Jennen-Steinmetz, Christine; Henze, Romy; Vomstein, Kilian; Haffner, Johann; Sieltjes, Bram

doi:10.3109/15622975.2011.591824

Cited by 84 publications

(91 citation statements)

References 50 publications

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“…This reduction in FA is in line with the findings of several previous studies in ASD ( Jeong et al, 2011;Jou et al, 2011aJou et al, , 2011bNoriuchi et al, 2010;Poustka et al, 2012;Shukla et al, 2011). Increased RD in the same tract in autism was also reported in a few previous studies ( Jeong et al, 2011;Shukla et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

“…For example, reduced FA in ASD participants has been linked to increased ASD symptom severity and behaviors (Catani et al, 2008;Noriuchi et al, 2010;Poustka et al, 2012;Thakkar et al, 2008), as well as performance intellectual quotient (PIQ) (Alexander et al, 2007;Lange et al, 2010;Lee et al, 2009). In addition, alterations in FA in participants with ASD have been related to language abilities (Fletcher et al, 2010;Li et al, 2014;Mills et al, 2013), executive functions (Nair et al, 2015), and motor performance (Thompson et al, 2016).…”

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confidence: 99%

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White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder

et al. 2016

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder found to have widespread alterations in the function and synchrony of brain regions. These differences may underlie alterations in microstructural organization, such as in white matter pathways. To investigate the diffusion of major white matter tracts, the current study examined multiple indices of white matter diffusion in 42 children and adults with ASD and 44 typically developing (TD) age-and IQ-matched peers using diffusion tensor imaging. Diffusivity measures were compared between groups for the following tracts: bilateral cingulum bundle, corpus callosum, inferior longitudinal fasciculus, superior longitudinal fasciculus, and uncinate fasciculus. Results indicate a significant reduction in fractional anisotropy (FA) for the left superior longitudinal fasciculus (LSLF) in ASD children and adults compared with TD peers. A significant increase in radial diffusivity for ASD participants was also found in the same cluster along the LSLF. In addition, a significant positive correlation emerged for all subjects between FA for the LSLF and age, with FA increasing with age. These findings point to a significant alteration in long-distance white matter connectivity in children and adults with ASD, potentially underscoring the relationship between alterations in white matter diffusion and the ASD phenotype. These results also suggest that the white matter alterations in autism may be subtle and related to the developmental trajectory.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder

et al. 2016

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“…Furthermore, we expected group status to moderate the association between abnormal white matter structure in the left uncinate and socio-affective deficits. In particular, we expected white matter structure in the left uncinate to be linked to socio-affective skills in individuals with ASD, but not in TD individuals, since brain behavior associations are more frequently identified in individuals with neuropsychiatric disorders when compared to neurotypicals (Baur et al, 2011;Poustka et al, 2012;Thomason and Thompson, 2011). To test specificity of group effects as well as moderating effects, we also analyzed group differences in the right uncinate fasciculus and tested moderation effects of group status on the association between white matter tissue structure in the uncinate fasciculi and another core feature of ASD, namely restricted and repetitive behaviors.…”

Section: The Current Studymentioning

confidence: 99%

“…It therefore connects basic emotion processing areas with regions involved in higher order processing, including emotion regulation. The uncinate has been linked to processing of emotional information in healthy populations (Frey et al, 2000), and has been reported to be related to impaired socio-emotional processing in disorders such as fronto-temporal dementia (Von der Heide et al, 2013), and also more generally with symptom severity in individuals with ASD (Poustka et al, 2012).…”

Section: Potential Neural Correlates Of Socio-affective Deficits In Amentioning

confidence: 99%

White matter structure in the uncinate fasciculus: Implications for socio-affective deficits in Autism Spectrum Disorder

Samson

Dougherty

Lee

et al. 2016

Psychiatry Research: Neuroimaging

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a b s t r a c tIndividuals with Autism Spectrum Disorder (ASD) have social and communication deficits and difficulties regulating emotions. The brain bases of these socio-affective deficits are not yet clear, but one candidate is structural connectivity in the left uncinate fasciculus, which connects limbic temporal and frontal areas thought to be involved in socio-affective processing. In this study, we assessed white matter structure in the left and right uncinate fasciculus in 18 high-functioning individuals with ASD and 18 group-matched typically developing (TD) controls using Diffusion Tensor Imaging. To test specificity of the associations, we also examined the association between both uncinate fasciculi and restricted and repetitive behaviors. Compared to TD individuals, individuals with ASD had significantly lower fractional anisotropy (FA) in the left and right uncinate. Group status significantly moderated the association between left uncinate and socio-affective deficits, indicating that within the ASD group, FA was associated with socio-affective deficits: Individuals with ASD with lower FA in the left uncinate had significantly more social and emotion regulation deficits. There was no association with restricted and repetitive behaviors. This study provides evidence that the left uncinate may play a critical role in socio-affective skills in individuals with ASD.

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“…However, analyzing structural connectivity and betweenness centrality in the same data set, differences in neuroanatomical areas spread over the whole brain (uncinate fasciculus, superior longitudinal fasciculus, Wernicke's area) were revealed [28,47]. Many of these affected areas belong to the heteromodal association cortex (HASC), such as altered connectivity in frontal and parietal areas by the uncinate and the superior longitudinal fasciculus and altered betweenness centrality in Wernicke's area.…”

Section: Aims and Hypothesesmentioning

confidence: 96%

Volumetric Alterations in the Heteromodal Association Cortex in Children with Autism Spectrum Disorder

et al. 2015

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Fronto-temporal disconnectivity and symptom severity in children with autism spectrum disorder

Abstract: Our findings support the hypothesis of abnormal white matter microstructure of fronto-temporal cortical networks in ASD, which are associated with core symptoms of the disorder.

Cited by 84 publications

References 50 publications

White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder

White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder

White matter structure in the uncinate fasciculus: Implications for socio-affective deficits in Autism Spectrum Disorder

Volumetric Alterations in the Heteromodal Association Cortex in Children with Autism Spectrum Disorder

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