Frontier of Epilepsy Research - mTOR signaling pathway

Cho, Chang Hoon

doi:10.3858/emm.2011.43.5.032

Cited by 84 publications

(67 citation statements)

References 600 publications

(397 reference statements)

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“…mTOR is important in a multitude of cellular processes, including cell growth and protein translation (6,14). A number of previous studies have investigated the nutrient regulation of mTORC1, and have indicated that mTORC1 exerts a vital influence on glucose metabolism (7,15).…”

Section: Discussionmentioning

confidence: 99%

Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis

Zhang¹,

Wei²,

Xi³

et al. 2015

Oncology Letters

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Abstract. The present study aimed to examine the relationship between mammalian target of rapamycin (mTOR) and glucose transporter 3 (Glut3) in the process of mTOR-mediated oncogenic glycolysis and tumorigenesis. Western blot analysis and quantitative polymerase chain reaction were used to compare the expression of Glut3 in mouse embryonic fibroblasts (MEFs) null for tuberous sclerosis complex 2 (Tsc2

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Section: Discussionmentioning

confidence: 99%

Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis

Zhang¹,

Wei²,

Xi³

et al. 2015

Oncology Letters

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“…Additionally, the cortical overgrowth in brain regions that were enlarged due to the genetic abnormality in the mceph/mceph mice was prevented by the treatment with carbamazepine. Furthermore, an alteration of the EGF/mTOR (mammalian target of rapamycin) signaling pathway has also been reported in the pathophysiology of epilepsy (Cho, 2011). Due to the direct inhibitory effects of the EGF/EGFR signaling pathways, the implication of Lingo-1 through the EGF-mTOR pathway also seems appropriate in the context of epilepsy.…”

Section: Tuberous Sclerosis Focal Cortical Dysplasia and Temporal Lomentioning

confidence: 99%

A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders

Andrews

Fernandez

2015

Neuroscience & Biobehavioral Reviews

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Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions. Although playing a major role in developmental brain functions, the potential application of Lingo-1 as a therapeutic target for the treatment of neurological disorders has so far been underestimated. A number of preclinical studies have shown that various methods of antagonizing Lingo-1 results in neuronal and oligodendroglial survival, axonal growth and remyelination; however to date literature has only detailed applications of Lingo-1 targeted therapeutics with a focus primarily on myelination disorders such as multiple sclerosis and spinal cord injury; omitting important information regarding Lingo-1 signaling cofactors. Here, we provide for the first time a complete and thorough review of the implications of Lingo-1 signaling in a wide range of neurological and psychiatric disorders, and critically examine its potential as a novel therapeutic target for these disorders. Disciplines Medicine and Health Sciences | Social and Behavioral Sciences AbstractLeucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions. Although playing a major role in developmental brain functions, the potential application of Lingo-1 as a therapeutic target for the treatment of neurological disorders has so far been under-estimated. A number of preclinical studies have shown that various methods of antagonizing Lingo-1 results in neuronal and oligodendroglial survival, axonal growth and remyelination; however to date literature has only detailed applications of Lingo-1 targeted therapeutics with a focus primarily on myelination disorders such as multiple sclerosis and spinal cord injury; omitting important information regarding Lingo-1 signaling co-factors. Here, we provide for the first time a complete and thorough review of the implications of Lingo-1 signaling in a wide range of neurological and psychiatric disorders, and critically examine its potential as a novel therapeutic target for these disorders.

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“…However, conflicting data suggests that mTOR activation is not a universal finding in epilepsy, because several studies fail to show a benefit of rapamycin in mouse epilepsy models such as amygdalar stimulation (Sliwa et al 2012) and pilocarpine-induced seizures (Buckmaster and Lew 2011). Future studies to more fully define how mTOR signaling fosters epileptogenesis may provide hope for using mTOR inhibitors as antiepileptogenic drugs to prevent the onset of seizures and/or halt the regression of behavioral development in select clinical scenarios (Cho 2011;Galanopolou et al 2012).…”

Section: Mtor Malformations and Epileptogenesis: Distinct Mechanistmentioning

confidence: 99%

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

Crino

2015

Cold Spring Harbor Perspectives in Medicine

140

111

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Frontier of Epilepsy Research - mTOR signaling pathway

Cited by 84 publications

References 600 publications

Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis

Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis

A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

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