Front Cover: Direct and Regioselective Di‐α‐fucosylation on the Secondary Rim of β‐Cyclodextrin (Chem. Eur. J. 27/2019)

Abstract

A regioselective method to directly attach two fucosides to β‐cyclodextrin has been discovered. With seven positions available on the secondary rim, the major product turned out to display the 3A,3D substitution pattern. Molecular dynamics simulations of the nonasaccharide product revealed tilting and bending of the fucosylated cyclodextrin residues, suggesting some degree of flexibility in this novel glycocluster. More information can be found in the Full Paper by M. T. C. Walvoort et al. on page 6722.